Evidence map›Paper›PMID 39291416›Full record

ArticleJournal of the International Neuropsychological Society : JINS2024

Anxiety in late-life depression is associated with poorer performance across multiple cognitive domains.

Maria Kryza-Lacombe, Michelle T Kassel, Philip S Insel, Emma Rhodes, David Bickford, Emily Burns, Meryl A Butters, Duygu Tosun, Paul Aisen, Rema Raman and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maria Kryza-LacombeMental Illness Research Education and Clinical Centers, Veterans Affairs Medical Center, San Francisco, CA, USA.ORCID 0000-0001-6650-4031
Michelle T KasselMental Illness Research Education and Clinical Centers, Veterans Affairs Medical Center, San Francisco, CA, USA.
Philip S InselDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Emma RhodesMental Illness Research Education and Clinical Centers, Veterans Affairs Medical Center, San Francisco, CA, USA.
David BickfordDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Emily BurnsDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Meryl A ButtersDepartment of Psychiatry Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Duygu TosunVeterans Affairs Medical Center, San Francisco, CA, USA.
Paul AisenUniversity of Southern California, Los Angeles, CA, USA.
Rema RamanUniversity of Southern California, Los Angeles, CA, USA.
Andrew J SaykinIndiana Alzheimer's Disease Research Center and Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-1376-8532
Arthur W TogaLaboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Michael W WeinerDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Craig NelsonDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
R Scott MackinDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LON S SCHNEIDER · 2020 to 2026
$27.8M
Characterizing Cognitive Decline in Late Life Depression: The ADNI-D ProjectR01MH098062 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Robert Scott Mackin · 2013 to 2026
$9.1M
High Capacity, High Performance Storage System for NeuroscienceS10OD032285 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2022 to 2022
$1.7M
Digital monitoring of autonomic activity to detect empathy loss in behavioral variant frontotemporal dementiaK23AG083124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Emma Rhodes · 2023 to 2026
$652k
NIA NIH HHS K23 AG083124NIA NIH HHS P30 AG066530NIH HHS S10 OD032285NIMH NIH HHS R01 MH098062
6 · The paper itself

Abstract

objectiveAnxiety is a common comorbid feature of late-life depression (LLD) and is associated with poorer global cognitive functioning independent of depression severity. However, little is known about whether comorbid anxiety is associated with a domain-specific pattern of cognitive dysfunction. We therefore examined group differences (LLD with and without comorbid anxiety) in cognitive functioning performance across multiple domains.

methodOlder adults with major depressive disorder (

resultsSignificant group differences emerged for confrontation naming and visuospatial functioning, as well as for verbal fluency, working memory, and inhibition with lower performance for LLD with comorbid anxiety compared to LLD only, controlling for depression severity.

conclusionsPerformance patterns identified among older adults with LLD and comorbid anxiety resemble neuropsychological profiles typically seen in neurodegenerative diseases of aging. These findings have potential implications for etiological considerations in the interpretation of neuropsychological profiles.

Indexed as

AnxietyMajor Depressive DisorderAgedAged, 80 and overCognitive DysfunctionComorbidityFemaleHumansMaleNeuropsychological TestsPsychiatric Status Rating ScalesanxietycognitionLate-life depressionneurodegenerationneuropsychological functioningolder adults

Identifiers

PMID39291416
PMCPMC11735324

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.