Evidence map›Paper›PMID 39291378›Full record

ArticleHypertension (Dallas, Tex. : 1979)2024

Systolic Blood Pressure, Cardiovascular Health, and Neurocognition in Adolescents.

Stephen R Hooper, Marc B Lande, Joseph T Flynn, Coral D Hanevold, Kevin E Meyers, Joshua Samuels, Richard C Becker, Stephen R Daniels, Bonita E Falkner, Michael A Ferguson and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Stephen R HooperUniversity of North Carolina-Chapel Hill (S.R.H.).
Marc B LandeUniversity of Rochester Medical Center (M.B.L.).ORCID 0000-0002-9467-5994
Joseph T FlynnDepartment of Pediatrics, University of Washington School of Medicine, and Division of Nephrology, Seattle Children's Hospital (J.T.F., C.D.H.).ORCID 0000-0001-7232-7975
Coral D HanevoldDepartment of Pediatrics, University of Washington School of Medicine, and Division of Nephrology, Seattle Children's Hospital (J.T.F., C.D.H.).ORCID 0000-0002-2795-1530
Kevin E MeyersChildren's Hospital of Philadelphia and University of Pennsylvania (K.E.M.).ORCID 0000-0001-6653-269X
Joshua SamuelsMcGovern Medical School at University of Texas Health and Children's Memorial Hermann Hospital, Houston (J. Samuels).ORCID 0000-0001-5682-4701
Richard C BeckerCincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine (R.C.B., L.J.M., M.M., P.K., J. Seo, E.M.U.).ORCID 0000-0002-9878-7707
Stephen R DanielsChildren's Hospital Colorado, Denver (S.R.D.).ORCID 0000-0001-5520-6952
Bonita E FalknerThomas Jefferson University, Philadelphia, PA (B.E.F.).ORCID 0000-0002-4242-4931
Michael A FergusonBoston Children's Hospital (M.A.F.).ORCID 0000-0002-8751-3348
Julie R IngelfingerMassachusetts General Hospital, Boston (J.R.I.).ORCID 0000-0001-9039-2703
Lisa J MartinCincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine (R.C.B., L.J.M., M.M., P.K., J. Seo, E.M.U.).
Mark MitsnefesCincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine (R.C.B., L.J.M., M.M., P.K., J. Seo, E.M.U.).ORCID 0000-0002-9904-0250
Phillip KhouryCincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine (R.C.B., L.J.M., M.M., P.K., J. Seo, E.M.U.).
Jangdong SeoCincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine (R.C.B., L.J.M., M.M., P.K., J. Seo, E.M.U.).ORCID 0000-0002-2758-1568
Elaine M UrbinaCincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine (R.C.B., L.J.M., M.M., P.K., J. Seo, E.M.U.).ORCID 0000-0002-5640-6777

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
American Heart Association-American Stroke Association 15SFRN23680000NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 TR002001NCATS NIH HHS UL1 TR002319
6 · The paper itself

Abstract

backgroundWe studied whether increased systolic blood pressure (SBP), as determined by auscultatory SBP, ambulatory SBP, and the number of cardiovascular health risk indicators, are associated with neurocognition in adolescents.

methodsThis cross-sectional study included 365 adolescents (mean age, 15.5 years) from 6 academic medical centers in the United States. The sample was 59.5% male, 52.6% White, with 23.9% of the caregivers having less than or equal to a high school degree. Primary exposures included the following: auscultatory SBP, ambulatory SBP, and the number of cardiovascular risk factors. Neurocognitive outcomes comprised nonverbal IQ, attention, and parent ratings of executive functions.

resultsAfter examining the models for the effects of targeted covariates (eg, maternal education), higher auscultatory SBP was associated with lower nonverbal IQ (β=-1.39;

conclusionsElevated SBP, even below the hypertension range, and general cardiovascular health are associated with neurocognitive outcomes in adolescents. How these findings might guide clinical care is worthy of additional study.

Indexed as

Blood PressureHypertensionAdolescentAttentionBlood Pressure Monitoring, AmbulatoryCardiovascular DiseasesCognitionCross-Sectional StudiesExecutive FunctionFemaleHeart Disease Risk FactorsHumansMaleRisk FactorsSystoleUnited Statesadolescenceambulatory blood pressurecardiovascular health riskhypertensionneurocognition

Identifiers

PMID39291378
PMCPMC11578784

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.