Evidence map›Paper›PMID 39291165›Full record

ArticleBrain communications2024

Cerebrovascular and Alzheimer's disease biomarkers in dementia with Lewy bodies and other dementias.

Anna Rennie, Urban Ekman, Sara Shams, Lina Rydén, Jessica Samuelsson, Anna Zettergren, Silke Kern, Ketil Oppedal, Frédéric Blanc, Jakub Hort and 18 more

Abstract read
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Review
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Article
  12. Co-pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Anna RennieDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0002-0976-8062
Urban EkmanDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.
Sara ShamsDepartment of Radiology, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Lina RydénNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 431 41 Mölndal, Sweden.ORCID https://orcid.org/0000-0002-3817-2620
Jessica SamuelssonNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 431 41 Mölndal, Sweden.
Anna ZettergrenNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 431 41 Mölndal, Sweden.
Silke KernNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 431 41 Mölndal, Sweden.
Ketil OppedalCenter for Age-Related Medicine, Stavanger University Hospital, 4011 Stavanger, Norway.
Frédéric BlancDay Hospital of Geriatrics, Memory Resource and Research Centre (CM2R) of Strasbourg, Department of Geriatrics, Hopitaux Universitaires de Strasbourg, 67098 Strasbourg, France.
Jakub HortMemory Clinic, Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic.
Sara Garcia-PtacekDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.
Angelo AntoniniParkinson and Movement Disorders Unit, Study Center on Neurodegeneration (CESNE), 35129 Padova, Italy.ORCID https://orcid.org/0000-0003-1040-2807
Afina W LemstraAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location Vumc, 1081 HV Amsterdam, The Netherlands.
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences (DSCS), University of Brescia, 25123 Brescia, Italy.
Milica Gregoric KrambergerDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.
Irena RektorováApplied Neuroscience Research Group, CEITEC, Masaryk University, 625 00 Brno, Czech Republic.
Zuzana WalkerDivision of Psychiatry, University College London, W1T 7NF London, UK.
Jón SnædalMemory Clinic, Landspitali, 105 Reykjavik, Iceland.
Matteo PardiniDepartment of Neurology, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
John-Paul TaylorTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE1 7RU Newcastle upon Tyne, UK.
Laura BonanniDepartment of Medicine, Aging Sciences University G. d'Annunzio of Chieti-Pescara Chieti, 66100 Chieti, Italy.
Tobias GranbergDepartment of Radiology, Karolinska University Hospital, 171 76 Stockholm, Sweden.ORCID https://orcid.org/0000-0001-6700-1022
Dag AarslandCenter for Age-Related Medicine, Stavanger University Hospital, 4011 Stavanger, Norway.
Ingmar SkoogNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 431 41 Mölndal, Sweden.
Lars-Olof WahlundDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.
Miia KivipeltoDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.
Eric WestmanDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0002-3115-2977
Daniel FerreiraDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0001-9522-4338

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Co-pathologies are common in dementia with Lewy bodies and other dementia disorders. We investigated cerebrovascular and Alzheimer's disease co-pathologies in patients with dementia with Lewy bodies in comparison with patients with mild cognitive impairment, Alzheimer's disease, mixed dementia, vascular dementia or Parkinson's disease with dementia and cognitively unimpaired participants. We assessed the association of biomarkers of cerebrovascular and Alzheimer's disease co-pathologies with medial temporal atrophy and global cognitive performance. Additionally, we evaluated whether the findings were specific to dementia with Lewy bodies. We gathered a multi-cohort dataset of 4549 participants (dementia with Lewy bodies = 331, cognitively unimpaired = 1505, mild cognitive impairment = 1489, Alzheimer's disease = 708, mixed dementia = 268, vascular dementia = 148, Parkinson's disease with dementia = 120) from the MemClin Study, Karolinska Imaging in Dementia Study, Gothenburg H70 Birth Cohort Studies and the European DLB Consortium. Cerebrovascular co-pathology was assessed with visual ratings of white matter hyperintensities using the Fazekas scale through structural imaging. Alzheimer's disease biomarkers of β-amyloid and phosphorylated tau were assessed in the cerebrospinal fluid for a subsample (

Indexed as

atrophyimagingmulti-cohortnaturalistic cohort

Identifiers

PMID39291165
PMCPMC11406466

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.