Evidence map›Paper›PMID 39290640›Full record

ArticleEClinicalMedicine2024

Cardiac manifestations and outcomes of COVID-19 vaccine-associated myocarditis in the young in the USA: longitudinal results from the Myocarditis After COVID Vaccination (MACiV) multicenter study.

Supriya S Jain, Steven A Anderson, Jeremy M Steele, Hunter C Wilson, Juan Carlos Muniz, Jonathan H Soslow, Rebecca S Beroukhim, Victoria Maksymiuk, Xander Jacquemyn, Olivia H Frosch and 53 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

63 authors.

Supriya S JainDepartment of Pediatrics, Division of Cardiology, New York Medical College-Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, USA.
Steven A AndersonThe U.S. Food and Drug Administration, Silver Spring, MD, USA.
Jeremy M SteeleYale University School of Medicine, New Haven, CT, USA.
Hunter C WilsonEmory University School of Medicine, Sibley Heart Center, Atlanta, GA, USA.
Juan Carlos MunizNicklaus Children's Hospital, Miami, FL, USA.
Jonathan H SoslowVanderbilt University Medical Center, Nashville, TN, USA.
Rebecca S BeroukhimDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Victoria MaksymiukDepartment of Pediatrics, Division of Cardiology, New York Medical College-Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, USA.
Xander JacquemynDepartment of Pediatrics, Johns Hopkins School of Medicine, Helen B. Taussig Heart Center, Johns Hopkins Hospital, Baltimore, MD, USA.
Olivia H FroschUniversity of Michigan Medical School, C.S. Mott Children's Hospital, Ann Arbor, MI, USA.
Brian FonsecaChildren's Hospital Colorado, Aurora, CO, USA.
Ashraf S HarahshehChildren's National Hospital and the George Washington University School of Medicine & Health Sciences, WA, USA.
Sujatha BuddheSeattle Children's Hospital, Seattle, WA, USA.
Ravi C AshwathUniversity of Iowa Stead Family Children's Hospital, Iowa City, IA, USA.
Deepika ThackerNemours Children's Health/Nemours Cardiac Center, Wilmington, DE, USA.
Shiraz A MaskatiaLucile Packard Children's Hospital, Stanford, Palo Alto, CA, USA.
Nilanjana MisraCohen Children's Medical Center, Northwell Health, New York, USA.
Jennifer A SuChildren's Hospital of Los Angeles, Los Angeles, CA, USA.
Saira SiddiquiGoryeb Children's Hospital, Morristown, NJ, USA.
Danish VaiyaniThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Aswathy K Vaikom-HouseThe University of Oklahoma Health Science Oklahoma City, Oklahoma, USA.
M Jay CampbellDivision of Pediatric Cardiology, Department of Pediatrics, Duke University, Durham, NC, USA.
Jared KleinJoe DiMaggio Children's Hospital, Hollywood, FL, USA.
Sihong HuangBetz Congenital Health Center, Helen DeVos Children's Hospital, Grand Rapids, MI, USA.
Christopher MathisChildren's Mercy Kansas City, Kansas City, MO, USA.
Matthew D CornicelliAnn & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Madhu SharmaThe Children's Hospital at Montefiore Bronx, New York, USA.
Lakshmi NagarajuUC Davis Children's Hospital, Sacramento, CA, USA.
Jocelyn Y AngRiley Hospital for Children, Indianapolis, IN, USA.
Santosh C UppuThe University of Texas Health Science Center, Children's Heart Institute, Houston, TX, USA.
Preeti RamachandranKentucky Children's Hospital, University of Kentucky, Lexington, KY, USA.
Jyoti K PatelChildren's Hospital of Michigan, Detroit, MI, USA.
Frank HanUniversity of Illinois College of Medicine, Peoria, IL, USA.
Jason G MandellUniversity of Rochester-Golisano Children's Hospital, Rochester, NY, USA.
Jyothsna Akam-VenkataUniversity of Mississippi Medical Center, Jackson, MS, USA.
Michael P DiLorenzoColumbia University, New York, NY, USA.
Michael BrumundLouisiana State University Health Sciences Center, Children's Hospital New Orleans, New Orleans, LA, USA.
Puneet BhatlaNYU Langone Health, Hassenfeld Children's Hospital, New York, NY, USA.
Parham EshtehardiNorthside Hospital Heart Institute, Atlanta, GA, USA.
Karina MehtaDivision of Cardiology, Department of Pediatrics, Oregon Health and Science University-Doernbecher Children's Hospital, Portland, OR, USA.
Katherine GloverYale University School of Medicine, New Haven, CT, USA.
Matthew L DoveEmory University School of Medicine, Sibley Heart Center, Atlanta, GA, USA.
Khalifah A AldawsariNicklaus Children's Hospital, Miami, FL, USA.
Anupam KumarVanderbilt University Medical Center, Nashville, TN, USA.
Spencer B BarfussDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Adam L DorfmanUniversity of Michigan Medical School, C.S. Mott Children's Hospital, Ann Arbor, MI, USA.
Prashant K MinochaChildren's Hospital Colorado, Aurora, CO, USA.
Alexandra B YontsChildren's National Hospital and the George Washington University School of Medicine & Health Sciences, WA, USA.
Jenna SchauerSeattle Children's Hospital, Seattle, WA, USA.
Andrew L ChengChildren's Hospital of Los Angeles, Los Angeles, CA, USA.
Joshua D RobinsonAnn & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Zachary PowellThe University of Oklahoma Health Science Oklahoma City, Oklahoma, USA.
Shubhika SrivastavaNemours Children's Health/Nemours Cardiac Center, Wilmington, DE, USA.
Anjali ChelliahGoryeb Children's Hospital, Morristown, NJ, USA.
Yamuna SanilRiley Hospital for Children, Indianapolis, IN, USA.
Lazaro E HernandezJoe DiMaggio Children's Hospital, Hollywood, FL, USA.
Lasya GaurDepartment of Pediatrics, Johns Hopkins School of Medicine, Helen B. Taussig Heart Center, Johns Hopkins Hospital, Baltimore, MD, USA.
Michael AntonchakNYU Langone Health, Hassenfeld Children's Hospital, New York, NY, USA.
Marla JohnstonLouisiana State University Health Sciences Center, Children's Hospital New Orleans, New Orleans, LA, USA.
Jonathan D ReichThe U.S. Food and Drug Administration, Silver Spring, MD, USA.
Narayan NairThe U.S. Food and Drug Administration, Silver Spring, MD, USA.
Elizabeth D DruggeDepartment of Pediatrics, Division of Cardiology, New York Medical College-Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, USA.
Lars Grosse-WortmannDivision of Cardiology, Department of Pediatrics, Oregon Health and Science University-Doernbecher Children's Hospital, Portland, OR, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Background: We aimed to study the clinical characteristics, myocardial injury, and longitudinal outcomes of COVID-19 vaccine-associated myocarditis (C-VAM). Methods: In this longitudinal retrospective observational cohort multicenter study across 38 hospitals in the United States, 333 patients with C-VAM were compared with 100 patients with multisystem inflammatory syndrome in children (MIS-C). We included patients ≤30 years of age with a clinical diagnosis of acute myocarditis after COVID-19 vaccination based on clinical presentation, abnormal biomarkers and/or cardiovascular imaging findings. Demographics, past medical history, hospital course, biochemistry results, cardiovascular imaging, and follow-up information from April 2021 to November 2022 were collected. The primary outcome was presence of myocardial injury as evidenced by late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging. Findings: Patients with C-VAM were predominantly white (67%) adolescent males (91%, 15.7 ± 2.8 years). Their initial clinical course was more likely to be mild (80% vs. 23%, p < 0.001) and cardiac dysfunction was less common (17% vs. 68%, p < 0.0001), compared to MIS-C. In contrast, LGE on CMR was more prevalent in C-VAM (82% vs. 16%, p < 0.001). The probability of LGE was higher in males (OR 3.28 [95% CI: 0.99, 10.6, p = 0.052]), in older patients (>15 years, OR 2.74 [95% CI: 1.28, 5.83, p = 0.009]) and when C-VAM occurred after the first or second dose as compared to the third dose of mRNA vaccine. Mid-term clinical outcomes of C-VAM at a median follow-up of 178 days (IQR 114-285 days) were reassuring. No cardiac deaths or heart transplantations were reported until the time of submission of this report. LGE persisted in 60% of the patients at follow up. Interpretation: Myocardial injury at initial presentation and its persistence at follow up, despite a mild initial course and favorable mid-term clinical outcome, warrants continued clinical surveillance and long-term studies in affected patients with C-VAM. Funding: The U.S. Food and Drug Administration.

Indexed as

Cardiac MRICOVID-19 vaccine-associated myocarditisLGE late gadolinium enhancementMIS-C multisystem inflammatory syndrome in childrenMyocardial injuryMyocarditis

Identifiers

PMID39290640
PMCPMC11406334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.