Evidence map›Paper›PMID 39290495›Full record

ArticleOpen life sciences2024

PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection.

Yun Wang, Yi Xu, Tun Zhao, Ya-Jun Ma, Wei Qin, Wen-Li Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open life sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yun WangDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Yi XuDepartment of Pharmacy, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Tun ZhaoDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Ya-Jun MaDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Wei QinDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Wen-Li HuDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intensive care unit-acquired weakness (ICU-AW) is prevalent in critical care, with limited treatment options. Certain microRNAs, like miR-542, are highly expressed in ICU-AW patients. This study investigates the regulatory role and mechanisms of miR-542 in ICU-AW and explores the clinical potential of miR-542 inhibitors. ICU-AW models were established in C57BL/6 mice through cecal ligation and puncture (CLP) and in mouse C2C12 myoblasts through TNF-α treatment.

Indexed as

ATG5cellular autophagyintensive care unit- acquired weaknessMiR-542mitochondrial damage

Identifiers

PMID39290495
PMCPMC11406224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.