Evidence map›Paper›PMID 39290166›Full record

ArticleCurrent eye research2025

Development of Microcystoid Macular Degeneration in the Retina of Nonhuman Primates: Time-Course and Associated Pathologies.

Thomas C M Lavery, Carol A Rasmussen, Alexander W Katz, Charlene B Y Kim, James N Ver Hoeve, Paul E Miller, Peter J Sonnentag, Brian J Christian, Christopher J Murphy, David R Piwnica-Worms and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Preexisting Fundus Findings in a Large Cohort of Young Cynomolgus Macaques (Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Thomas C M LaveryDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Carol A RasmussenDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Alexander W KatzDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Charlene B Y KimDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
James N Ver HoeveDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Paul E MillerOcular Services On Demand (OSOD), LLC, Madison, WI, USA.
Peter J SonnentagLabcorp Preclinical Drug Development, Madison, WI, USA.
Brian J ChristianOcular Services On Demand (OSOD), LLC, Madison, WI, USA.
Christopher J MurphyOcular Services On Demand (OSOD), LLC, Madison, WI, USA.
David R Piwnica-WormsDepartment of Cancer Systems Imaging, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Seth T GammonDepartment of Cancer Systems Imaging, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Xudong QiuDepartment of Cancer Systems Imaging, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Paul L KaufmanDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
T Michael NorkDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 1985 to 2011
$106.7M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2005 to 2026
$12.6M
MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTIONR01EY019587 · NEI · WASHINGTON UNIVERSITY · PI PIWNICA-WORMS, DAVID · 2009 to 2022
$5.3M
[18F]4FN PET Imaging of Innate Immunity Activation During Immunotherapy-Induced Adverse EventsR01CA273130 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NEELAPU, SATTVA S, PIWNICA-WORMS, DAVID · 2022 to 2025
$2.7M
Enhancing Basic and Translational Vision Research Using AnimalsS10OD026957 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI BRANDT, CURTIS R · 2019 to 2019
$529k
NCI NIH HHS R01 CA273130NCRR NIH HHS P51 RR000167NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY019587NIH HHS P51 OD011106NIH HHS S10 OD026957
6 · The paper itself

Abstract

purposeMicrocystoid macular degeneration (MMD) is a condition where cystoid vacuoles develop within the inner nuclear layer of the retina in humans in a variety of disorders. Here we report the occurrence of MMD in non-human primates (NHPs) with various retinal ganglion cell (RGC) pathologies and evaluate the hypothesis that MMD does not precede RGC loss but follows it.

methodsMorphological studies were performed of the retinas of NHPs, specifically both rhesus (

resultsMMD, like that seen on OCT scans of humans, was found in both rhesus and cynomolgus macaques with EG. Of 13 cynomolgus macaques with chronic EG imaged once with OCT six of 13 animals were noted to have MMD. MMD was also evident in a cynomolgus macaque with bilateral optic atrophy. Following HEA, MMD did not develop until at least 2 weeks following the RNFL loss.

conclusionThese data suggest that MMD may be caused by a retrograde trans-synaptic process related to RGC loss. MMD is not associated with inflammation, nor would it be an independent indicator of drug toxicity

Indexed as

Disease Models, AnimalFluorescein AngiographyMacaca fascicularisMacaca mulattaMacular DegenerationRetinal Ganglion CellsTomography, Optical CoherenceAnimalsAxotomyGlaucomaMaleOphthalmoscopyOptic AtrophyRetinaTime FactorsVacuolesendodiathermy axotomyexperimental glaucomainner nuclear layerMicrocystic macular degenerationoptic atrophy

Identifiers

PMID39290166
PMCPMC11666409

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.