Evidence map›Paper›PMID 39290062›Full record

Observational studyJournal of surgical oncology2024

Comprehensive Geriatric Assessment, Treatment Decisions, and Outcomes in Older Patients Eligible for Pancreatic Surgery.

Marij Hartog, Sara J E Beishuizen, Reon Togo, Rozemarijn L van Bruchem-Visser, Casper H J van Eijck, Francesco U S Mattace-Raso, Chulja J Pek, Roeland F de Wilde, Bas Groot Koerkamp, Harmke A Polinder-Bos

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Postoperative delirium in patients with cancer: a narrative review of major risk factors.Sao Paulo medical journal = Revista paulista de medicina · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marij HartogDepartment of Internal Medicine, Division of Geriatric Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0009-0000-4386-4683
Sara J E BeishuizenGeriant, Alkmaar, The Netherlands.
Reon TogoDepartment of Internal Medicine, Division of Geriatric Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Rozemarijn L van Bruchem-VisserDepartment of Internal Medicine, Division of Geriatric Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Casper H J van EijckDepartment of Surgery, Erasmus MC Cancer Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Francesco U S Mattace-RasoDepartment of Internal Medicine, Division of Geriatric Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Chulja J PekDepartment of Surgery, Erasmus MC Cancer Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Roeland F de WildeDepartment of Surgery, Erasmus MC Cancer Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Bas Groot KoerkampDepartment of Surgery, Erasmus MC Cancer Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Harmke A Polinder-BosDepartment of Internal Medicine, Division of Geriatric Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPeriampullary cancer has a poor prognosis. Surgical resection is a potentially curative but high-risk treatment. Comprehensive geriatric assessment (CGA) can inform treatment decisions, but has not yet been evaluated in older patients eligible for pancreatic surgery.

methodsThis prospective observational study included patients ≥ 70 years of age eligible for pancreatic surgery. Frailty was defined as impairment in at least two of five domains: somatic, psychological, functional, nutritional, and social. Outcomes included postoperative complications, functional decline, and mortality.

resultsOf the 88 patients included, 87 had a complete CGA. Sixty-five patients (75%) were frail and 22 (25%) were non-frail. Frail patients were more likely to receive nonsurgical treatment (43.1% vs. 9.1% p = 0.004). Fifty-seven patients underwent surgery, of which 52 (59%) underwent pancreaticoduodenectomy. The incidence of postoperative delirium was three times higher in frail patients (29.7% vs. 0%, p = 0.005). The risk of mortality was three times higher in frail patients (HR: 3.36, 95% CI: 1.43-7.89, p = 0.006).

conclusionFrailty is common in older patients eligible for pancreatic surgery and is associated with treatment decision, a higher incidence of delirium and a three times higher risk of all-cause mortality. CGA can contribute to shared decision-making and optimize perioperative care in older patients.

Indexed as

FrailtyGeriatric AssessmentPancreatic NeoplasmsPancreaticoduodenectomyAgedAged, 80 and overDecision MakingFemaleFrail ElderlyHumansMalePostoperative ComplicationsPrognosisProspective Studieselderlyfrailtyfunctional declinegeriatric oncologypancreatic cancerpancreatic surgeryperiampullary cancer

Identifiers

PMID39290062
PMCPMC11849714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.