Evidence map›Paper›PMID 39289946›Full record

ArticleCurrent cancer drug targets2025

Screening miRNAs to Hinder the Tumorigenesis of Renal Clear Cell Carcinoma Associated with KDR Expression.

Rangaraj Kaviyaprabha, Thandaserry Vasudevan Miji, Rangaraj Suseela, Sridhar Muthusami, Subramanian Thangaleela, Hesham S Almoallim, Priyadarshini Sivakumar, Muruganantham Bharathi

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Article in Current cancer drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Targeting miRNAs in renal cell carcinoma: emerging therapeutic strategies.International journal of clinical oncology · 2025
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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Rangaraj KaviyaprabhaCentre for Bioinformatics, Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India.
Thandaserry Vasudevan MijiCentre for Bioinformatics, Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India.
Rangaraj SuseelaCentre for Cancer Research, Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India.
Sridhar MuthusamiCentre for Cancer Research, Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India.ORCID 0000-0002-3595-9081
Subramanian ThangaleelaInstitute of Biotechnology, Department of Medical Biotechnology and Integrative Physiology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, 602 105, Tamil Nadu, India.
Hesham S AlmoallimDepartment of Oral and Maxillofacial Surgery, College of Dentistry, King Saud University, PO Box-60169, Riyadh -11545, Saudi Arabia.
Priyadarshini SivakumarDepartment of Microbiology, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India.
Muruganantham BharathiCentre for Bioinformatics, Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India.ORCID 0000-0003-3235-5837

Funding

King Saud University, Riyadh, Saudi Arabia RSP2024R283
6 · The paper itself

Abstract

introductionThis study delved to understand the role of Kinase Insert Domain Receptor (KDR) and its associated miRNAs in renal cell carcinoma through an extensive computational analysis. The potential of our findings to guide future research in this area is significant.

methodsOur methods, which included the use of UALCAN and GEPIA2 databases, as well as miRDB, MirDIP, miRNet v2.0, miRTargetLink, MiEAA v2.1, TarBase v8.0, INTERNET, and miRTarBase, were instrumental in identifying the regulation of miRNA associated with KDR expression. The predicted miRNA was validated with the TCGA-KIRC patients' samples by implementing CancerMIRNome. The TargetScanHuman v8.0 was implemented to identify the associations between human miRNAs and KDR. A Patch Dock server analyzed the interactions between hsa-miR-200c-3p and KDR.

resultsThe KDR expression rate was investigated in the Kidney Renal Cell Carcinoma (KIRC) samples, and adjacent normal tissues revealed that the expression rate was significantly higher than the normal samples, which was evident from the strong statistical significance (P = 1.63e DISCUSSION: Upon examining the outcome, it became evident that miR-200c-3p was significantly downregulated in KIRC compared to the normal samples. Moreover, the negative correlation was obtained for hsa-miR-200c-3p (R = - 0.276) along with the KDR expression describing that the increased rate of hsamiR- 200c-3p might reduce the KDR expression rate, which may suppress the KIRC initiation or progression.

conclusionThe

Indexed as

Carcinoma, Renal CellKidney NeoplasmsMicroRNAsVascular Endothelial Growth Factor Receptor-2Biomarkers, TumorCarcinogenesisGene Expression Regulation, NeoplasticHumansBiomarkers, TumorKDR protein, humanMicroRNAsMIRN200 microRNA, humanVascular Endothelial Growth Factor Receptor-2computational kidneyKDRmiR-200c-3p.miRNArenal cell carcinomatumor grade potential regulator

Identifiers

PMID39289946

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