Evidence map›Paper›PMID 39289872›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2024

VSTM2A reverses immunosuppression in colorectal cancer by antagonizing the PD-L1/PD-1 interaction.

Yujuan Dong, Jiaxun Jade Liu, Yunfei Zhou, Wei Kang, Shanglin Li, Alvin H K Cheung, Yi Hu, Rui Liao, Nathalie Wong, Chi Chun Wong and 2 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yujuan DongInstitute of Digestive Disease, State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China; Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Jiaxun Jade LiuDepartment of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yunfei ZhouInstitute of Digestive Disease, State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wei KangDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Shanglin LiDepartment of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Alvin H K CheungDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yi HuDepartment of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China; Jiangxi Provincial Key Laboratory of Digestive Diseases, Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Rui LiaoDepartment of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Nathalie WongDepartment of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chi Chun WongInstitute of Digestive Disease, State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China.
Simon S M NgInstitute of Digestive Disease, State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China; Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: simonng@surgery.cuhk.edu.hk.
Jun YuInstitute of Digestive Disease, State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: junyu@cuhk.edu.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunoglobulin (Ig) VSTM2A (V-set and transmembrane domain containing 2A) is a top-ranked secretory protein frequently silenced during colorectal carcinogenesis; however, its role in immune modulation remains largely unknown. Bioinformatic and immunohistochemistry analysis of human colorectal specimens and Vstm2a

Indexed as

B7-H1 AntigenColorectal NeoplasmsProgrammed Cell Death 1 ReceptorAnimalsCell Line, TumorHumansImmunosuppression TherapyMembrane ProteinsMiceMice, KnockoutProtein BindingB7-H1 AntigenCD274 protein, humanMembrane ProteinsPDCD1 protein, humanProgrammed Cell Death 1 Receptorantagonistcolorectal cancercytotoxic T cellPD-L1VSTM2A

Identifiers

PMID39289872
PMCPMC11573612

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.