Evidence map›Paper›PMID 39289809›Full record

ArticleBiomacromolecules2024

Chaperone/Polymer Complexation of Protein-Based Fluorescent Nanoclusters against Silica Encapsulation-Induced Physicochemical Stresses.

Mohsen Akbarian, I-Ni Chen, Pei-Hsuan Lu, Quynh-Trang Do, Shun-Fen Tzeng, Ho-Hsuan Chou, Shu-Hui Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohsen AkbarianDepartment of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan.
I-Ni ChenDepartment of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan.
Pei-Hsuan LuDepartment of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan.
Quynh-Trang DoDepartment of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan.
Shun-Fen TzengDepartment of Life Science, National Cheng Kung University, Tainan 70101, Taiwan.
Ho-Hsuan ChouDepartment of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan.
Shu-Hui ChenDepartment of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0003-1871-9366

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silica encapsulation under ambient conditions is commonly used to shield protein-based nanosystems from chemical stress. However, encapsulation-induced photo- and structural instabilities at elevated temperatures have been overlooked. Using bovine serum albumin-capped fluorescent gold nanoclusters (BSA-AuNCs) as a model, we demonstrated that chaperone/polymer layer-by-layer complexation can stabilize the template to resist encapsulation-induced fragmentation/reorganization and emission increases at 37 °C or higher temperatures. We first wrapped BSA-AuNCs with α-crystallin chaperones (α-Crys) to gain the highest thermal stability at a 1:50 molar ratio and then enfolded BSA-AuNC/α-Crys with thermoresponsive poly-

Indexed as

Acrylic ResinsGoldMetal NanoparticlesSerum Albumin, BovineSilicon Dioxidealpha-CrystallinsAnimalsCattleFluorescent DyesHumansMolecular ChaperonesAcrylic Resinsalpha-CrystallinsFluorescent DyesGoldMolecular Chaperonespoly-N-isopropylacrylamideSerum Albumin, BovineSilicon Dioxide

Identifiers

PMID39289809
PMCPMC11480988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.