Evidence map›Paper›PMID 39289617›Full record

ArticleBMC cancer2024

Altered microbial diversity and composition of multiple mucosal organs in cervical cancer patients.

Lan Peng, Conghui Ai, Zhongyan Dou, Kangming Li, Meiping Jiang, Xingrao Wu, Chunfang Zhao, Zheng Li, Lan Zhang

Abstract read
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lan Peng *Department of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), 519 Kunzhou Road, Xishan District, Kunming, 650118, China.
Conghui Ai *Department of Radiology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), 519 Kunzhou Road, Xishan District, Kunming, 650118, China.
Zhongyan Dou *Department of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), 519 Kunzhou Road, Xishan District, Kunming, 650118, China.
Kangming LiDepartment of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), 519 Kunzhou Road, Xishan District, Kunming, 650118, China.
Meiping JiangDepartment of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), 519 Kunzhou Road, Xishan District, Kunming, 650118, China.
Xingrao WuDepartment of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), 519 Kunzhou Road, Xishan District, Kunming, 650118, China.
Chunfang ZhaoDepartment of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), 519 Kunzhou Road, Xishan District, Kunming, 650118, China.
Zheng LiDepartment of Gynecologic Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), 519 Kunzhou Road, Xishan District, Kunming, 650118, China. lizheng@kmmu.edu.cn.
Lan ZhangDepartment of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), 519 Kunzhou Road, Xishan District, Kunming, 650118, China. zhanglan@kmmu.edu.cn.

Funding

Innovative Research Team of Yunnan Province 202305AS350020National Natural Science Foundation of China 82160562Yunnan Fundamental Research Projects 202201AT070009
6 · The paper itself

Abstract

objectivesThe aim of this study was to characterize the microbiome of multiple mucosal organs in cervical cancer (CC) patients.

methodsWe collected oral, gut, urinary tract, and vaginal samples from enrolled study participants, as well as tumor tissue from CC patients. The microbiota of different mucosal organs was identified by 16S rDNA sequencing and correlated with clinical-pathological characteristics of cervical cancer cases.

resultsCompared with controls, CC patients had reduced α-diversity of oral and gut microbiota (p

conclusionsOur study not only revealed differences in the composition and diversity of the vaginal and gut microflora between CC cases and controls, but also showed dysbiosis of the oral cavity and urethra in cervical cancer cases.

Indexed as

MicrobiotaUterine Cervical NeoplasmsAdultAgedBacteriaBiodiversityCase-Control StudiesFemaleGastrointestinal MicrobiomeHumansMiddle AgedMouthMucous MembraneRNA, Ribosomal, 16SUrinary TractVaginaRNA, Ribosomal, 16S16S rDNA sequencingCervical cancerDysbiosisMulti-organ microbiome

Identifiers

PMID39289617
PMCPMC11409810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.