Evidence map›Paper›PMID 39289508›Full record

ArticleNature microbiology2024

Silencing the transcriptionally active HIV reservoir to improve treatment outcomes.

Julia Prigann, Rubens Tavora, Robert L Furler O'Brien, Ursula Schulze-Gahmen, Daniela Boehm, Nadia R Roan, Douglas F Nixon, Lishomwa C Ndhlovu, Susana Valente, Melanie Ott

Abstract read
In one paragraph

Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia Prigann *Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA, USA.
Rubens Tavora *Department of Immunology and Microbiology, The Herbert Wertheim UF Scripps Research Institute for Biomedical Innovation and Technology, University of Florida, Jupiter, FL, USA.
Robert L Furler O'BrienGladstone Institute of Virology, Gladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5706-4871
Ursula Schulze-GahmenGladstone Institute of Virology, Gladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3919-4474
Daniela BoehmGladstone Institute of Virology, Gladstone Institutes, San Francisco, CA, USA.
Nadia R RoanGladstone Institute of Virology, Gladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5464-1976
Douglas F NixonFeinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.ORCID http://orcid.org/0000-0002-2801-1786
Lishomwa C NdhlovuDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. lndhlovu@med.cornell.edu.ORCID http://orcid.org/0000-0001-5427-4187
Susana ValenteDepartment of Immunology and Microbiology, The Herbert Wertheim UF Scripps Research Institute for Biomedical Innovation and Technology, University of Florida, Jupiter, FL, USA. svalente@ufl.edu.
Melanie OttGladstone Institute of Virology, Gladstone Institutes, San Francisco, CA, USA. melanie.ott@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0002-5697-1274

Funding

HOPE - HIV Obstruction by Programmed EpigeneticsUM1AI164559 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI Lishomwa C Ndhlovu, Melanie Maria Ott · 2021 to 2026
$32.2M
Evaluation of didehydro-Cortistatin A as a block-and-lock agent for a functional HIV cure in a macaque modelR01AI167732 · NIAID · UNIVERSITY OF FLORIDA · PI David T Evans, Susana T Valente · 2021 to 2026
$4.3M
Host factors regulating HIV latency and reactivationR37AI165137 · NIAID · UNIVERSITY OF FLORIDA · PI Susana T Valente · 2022 to 2026
$2.0M
NIAID NIH HHS R01 AI167732NIAID NIH HHS R37 AI165137NIAID NIH HHS UM1 AI164559U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) UM1AI164559
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HIV-1HIV InfectionsAnti-HIV AgentsCD4-Positive T-LymphocytesHumansTranscription, GeneticTreatment OutcomeVirus LatencyAnti-HIV Agents

Identifiers

PMID39289508
PMCPMC11841736

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.