Evidence map›Paper›PMID 39289469›Full record

ArticleScientific reports2024

Perfusion-weighted imaging with dynamic contrast enhancement (PWI/DCE) morphologic, qualitative, semiquantitative, and radiomics features predicting undifferentiated pleomorphic sarcoma (UPS) treatment response.

R F Valenzuela, E Duran-Sierra, M Canjirathinkal, B Amini, K E Torres, R S Benjamin, J Ma, W L Wang, K P Hwang, R J Stafford and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

R F ValenzuelaDepartment of Musculoskeletal Imaging, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
E Duran-SierraDepartment of Musculoskeletal Imaging, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
M CanjirathinkalDepartment of Musculoskeletal Imaging, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
B AminiDepartment of Musculoskeletal Imaging, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
K E TorresDepartment of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
R S BenjaminDepartment of Sarcoma Medical Oncology, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
J MaDepartment of Imaging Physics, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
W L WangDepartment of Anatomical Pathology, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
K P HwangDepartment of Imaging Physics, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
R J StaffordDepartment of Imaging Physics, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
C WuDepartment of Imaging Physics, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
A M ZarzourDepartment of Sarcoma Medical Oncology, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
A J BishopDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
S LoDepartment of Musculoskeletal Imaging, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
J E MadewellDepartment of Musculoskeletal Imaging, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
R KumarDepartment of Musculoskeletal Imaging, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
W A MurphyDepartment of Musculoskeletal Imaging, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.
C M CostelloeDepartment of Musculoskeletal Imaging, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1475, Houston, TX, 77030-4009, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Undifferentiated pleomorphic sarcoma (UPS) is the largest subgroup of soft tissue sarcomas. This study determined the value of perfusion-weighted imaging with dynamic-contrast-enhancement (PWI/DCE) morphologic, qualitative, and semiquantitative features for predicting UPS pathology-assessed treatment effect (PATE). This retrospective study included 33 surgically excised extremity UPS patients with pre-surgical MRI. Volumetric tumor segmentation from PWI/DCE was obtained at Baseline (BL), Post-Chemotherapy (PC), and Post-Radiation Therapy (PRT). The surgical specimens' PATE separated cases into Responders (R) (≥ 90%, 16 patients), Partial-Responders (PR) (89 - 31%, 10 patients), and Non-Responders (NR) (≤ 30%, seven patients). Seven semiquantitative kinetic parameters and maps were extracted from time-intensity curves (TICs), and 107 radiomic features were derived. Statistical analyses compared R vs. PR/NR. At PRT, 79% of R displayed a "Capsular" morphology (P = 1.49 × 10

Indexed as

Contrast MediaSarcomaAdultAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRadiomicsRetrospective StudiesTreatment OutcomeContrast MediaDynamic contrast enhancement (DCE)Multiparametric MRIPathology-assessed treatment effect (PATE)Perfusion-weighted imaging (PWI)Soft tissue sarcoma (STS)Undifferentiated pleomorphic sarcoma (UPS)

Identifiers

PMID39289469
PMCPMC11408515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.