Evidence map›Paper›PMID 39289424›Full record

ArticleScientific reports2024

Y-box binding protein 1/cyclin A1 axis specifically promotes cell cycle progression at G

Yuichi Murakami, Daisuke Katsuchi, Taichi Matsumoto, Kuon Kanazawa, Tomohiro Shibata, Akihiko Kawahara, Jun Akiba, Nozomu Yanaihara, Aikou Okamoto, Hiroaki Itamochi and 7 more

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yuichi Murakami *Basic Medical Research Unit, St. Mary's Research Center, 422 Tsubukuhon-Machi, Kurume, Fukuoka, 830-8543, Japan. y-murakami@st-mary-med.or.jp.
Daisuke Katsuchi *Basic Medical Research Unit, St. Mary's Research Center, 422 Tsubukuhon-Machi, Kurume, Fukuoka, 830-8543, Japan.
Taichi MatsumotoBasic Medical Research Unit, St. Mary's Research Center, 422 Tsubukuhon-Machi, Kurume, Fukuoka, 830-8543, Japan.
Kuon KanazawaBasic Medical Research Unit, St. Mary's Research Center, 422 Tsubukuhon-Machi, Kurume, Fukuoka, 830-8543, Japan.
Tomohiro ShibataDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Akihiko KawaharaDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, 830-0011, Japan.
Jun AkibaDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, 830-0011, Japan.
Nozomu YanaiharaDepartment of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.
Aikou OkamotoDepartment of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.
Hiroaki ItamochiDepartment of Clinical Oncology, Iwate Medical University School of Medicine, Yahaba-Cho, 028-3694, Japan.
Toru SugiyamaDepartment of Obstetrics and Gynecology, St. Mary's Hospital, Kurume, 830-8543, Japan.
Atsumu TeradaDepartment of Obstetrics and Gynecology, St. Mary's Hospital, Kurume, 830-8543, Japan.
Shin NishioDepartment of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, 830-0011, Japan.
Naotake TsudaDepartment of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, 830-0011, Japan.
Kiyoko KatoDepartment of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Mayumi OnoBasic Medical Research Unit, St. Mary's Research Center, 422 Tsubukuhon-Machi, Kurume, Fukuoka, 830-8543, Japan.
Michihiko KuwanoBasic Medical Research Unit, St. Mary's Research Center, 422 Tsubukuhon-Machi, Kurume, Fukuoka, 830-8543, Japan.

Funding

Japan Society for the Promotion of Science 24K09909
6 · The paper itself

Abstract

Y-box binding protein 1 (YBX1) promotes oncogenic transformation and tumor growth. YBX1 plays a role in regulation of cell cycle promotion via upregulation of cell cycle-related genes. In ovarian cancer, YBX1 also promotes tumor growth, but the mechanisms of YBX1 in cell growth and cell cycle in ovarian cancer remain not to be fully understood. Here, we investigated whether YBX1-dependent cancer cell proliferation was specifically associated with expression of cell cycle related genes in ovarian cancer. Protein and mRNA expression levels of YBX1 and cell cycle-related genes in ovarian cancer cell lines and tissues were determined by western blot analysis, immunohistochemical analysis and reverse transcription-quantitative PCR. Cell cycle analysis was performed by flow cytometry. Luciferase assay and Chromatin immunoprecipitation assay were used to investigate a transcriptional function of YBX1. YBX1 silencing induced marked growth suppression in 4 cell lines (group A), moderate suppression in 5 cell lines (group B), and no suppression in 3 cell lines (group C) among 12 ovarian cancer cell lines in culture. The YBX1 silencing induced cell cycle arrest at G

Indexed as

Cell ProliferationCyclin A1Gene Expression Regulation, NeoplasticOvarian NeoplasmsY-Box-Binding Protein 1Cell Line, TumorFemaleG2 Phase Cell Cycle CheckpointsHumansCCNA1 protein, humanCyclin A1Y-Box-Binding Protein 1YBX1 protein, humanCell cycleCyclin A1G2/M arrestOvarian cancerYBX1

Identifiers

PMID39289424
PMCPMC11408696

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.