Evidence map›Paper›PMID 39289412›Full record

ArticleScientific reports2024

Interleukin 6 and interleukin 17A serum levels and gene- polymorphisms in the development of early allograft rejection in living donor liver transplant recipients.

Samah Mohammed Awad, Eman Helmy El Batanony, Shaimaa K Elmahdy, Esraa Tawfik Allam, Sara Kamal Rizk, Ahmed B Zaid, Mohammad Taha, Radwa H Salem

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samah Mohammed AwadClinical Microbiology and Immunology Department, National Liver Institute, Menoufia University, Shibin Elkom, 32511, Egypt.
Eman Helmy El BatanonyClinical Microbiology and Immunology Department, National Liver Institute, Menoufia University, Shibin Elkom, 32511, Egypt.
Shaimaa K ElmahdyGastroenterology and Hepatology Department, National Liver Institute, Menoufia University, Shibin Elkom, 32511, Egypt.
Esraa Tawfik AllamDepartments of Clinical Pathology, National Liver Institute, Menoufia University, Shibin Elkom, 32511, Egypt.
Sara Kamal RizkBiochemistry department, Faculty of Medicine, Menoufia University, Shibin Elkom, 32511, Egypt.
Ahmed B ZaidDepartments of Clinical Pathology, National Liver Institute, Menoufia University, Shibin Elkom, 32511, Egypt. ahmedzaid@liver.menofia.edu.eg.ORCID http://orcid.org/0000-0001-8268-4538
Mohammad TahaHepatopancreatobiliary and Liver Transplant Surgery, National Liver Institute, Shibin Elkom, 32511, Egypt.
Radwa H SalemClinical Microbiology and Immunology Department, National Liver Institute, Menoufia University, Shibin Elkom, 32511, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to evaluate the role of serum level of Interleukin 6(IL-6) and Interleukin 17 (IL-17) in liver transplantation outcome for living recipients, Analyze the relation between the gene polymorphism and the occurrence of rejection after liver transplantation and Study the relation between the gene polymorphism and the occurrence of different infectious complications. The study was conducted in March 2023 and included 60 healthy volunteers from the National Liver Institute (NLI) blood bank at Menoufia University and 120 live donation liver recipient patients at NLI. During one month of liver transplantation, the cytokine levels (IL-17, IL-6 proteins, IL-6 G-174C, and IL-17 A rs2275913 gene polymorphism) and CD4 levels for 60 patients of 120 live donation liver recipient patients whom early reject transplanted tissue and the same parameters were measured after 6 months follow up for non-reject group. The main finding of this study was that the post-transplant rejection group and the post-transplant non-rejection and control groups differed significantly in the genotype frequency (CC, CG, and GG) or alleles of IL-6 G-174C (p = 0.011). On the other hand IL-17A rs2275913 gene polymorphism and its alleles (p = 0.71) showed no statistically significant difference. We also observed that serum IL-17 levels, with 100% specificity and 100% sensitivity threshold, will be more sensitive and specific than serum IL-6 and CD4 count in differentiating post-transplant rejection from non-rejection patients. The results showed that there was no significant relationship between the genotypes and serum levels of interleukins and the type and degree of rejection. Proinflammatory cytokines might be useful indicators for distinguishing and early identifying unfavorable outcomes after transplantation, allowing for prompt and effective treatment intervention. To evaluate these findings, prospective clinical trials are required.

Indexed as

Graft RejectionInterleukin-17Interleukin-6Liver TransplantationLiving DonorsPolymorphism, Single NucleotideAdultAllelesAllograftsFemaleGenotypeHumansMaleMiddle AgedTransplant RecipientsIL17A protein, humanIL6 protein, humanInterleukin-17Interleukin-6Early allograft rejectionGene- polymorphismsInfectionsInterleukin 17AInterleukin 6Serum levels

Identifiers

PMID39289412
PMCPMC11408691

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.