Evidence map›Paper›PMID 39289373›Full record

ArticleNPJ Parkinson's disease2024

Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) clinical trial.

Scott Stanslaski, Rebekah L S Summers, Lisa Tonder, Ye Tan, Michelle Case, Robert S Raike, Nathan Morelli, Todd M Herrington, Martijn Beudel, Jill L Ostrem and 11 more

Registry-linked trialAbstract read
In one paragraph

Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04547712 (Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease), which is not on this map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04547712 nacompletednot on this map

Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD)

TypeinterventionalSponsorMedtronicNeuroRan2020 to 2025Enrolled85ConditionsParkinson DiseaseArmsAdaptive DBS
3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. The Place of Adaptive Deep Brain Stimulation in Parkinson's Disease: Spatial before Temporal Optimization.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  13. Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
    Article
  14. Closed-loop SCS and sensing: now and in the future.Pain medicine (Malden, Mass.) · 2026
    Review
  15. Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. From continuous to adaptive deep brain stimulation: Personalized modulation improves motor complications and sleep in Parkinson's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  20. Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Scott StanslaskiMedtronic Neuromodulation, Medtronic, Minneapolis, Minnesota, USA. scott.stanslaski@medtronic.com.ORCID http://orcid.org/0000-0002-3513-2391
Rebekah L S SummersMedtronic Neuromodulation, Medtronic, Minneapolis, Minnesota, USA.
Lisa TonderMedtronic Neuromodulation, Medtronic, Minneapolis, Minnesota, USA.
Ye TanMedtronic Neuromodulation, Medtronic, Minneapolis, Minnesota, USA.
Michelle CaseMedtronic Neuromodulation, Medtronic, Minneapolis, Minnesota, USA.
Robert S RaikeMedtronic Neuromodulation, Medtronic, Minneapolis, Minnesota, USA.
Nathan MorelliMedtronic Neuromodulation, Medtronic, Minneapolis, Minnesota, USA.
Todd M HerringtonMassachusetts General Hospital, Harvard Medical School, Boston, USA.
Martijn BeudelDepartment of Neurology, Amsterdam University Medical Centers, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0002-2488-7051
Jill L OstremDepartment of Neurology, University of California San Francisco, San Francisco, USA.
Simon LittleDepartment of Neurology, University of California San Francisco, San Francisco, USA.ORCID http://orcid.org/0000-0001-6249-6230
Leonardo AlmeidaDepartment of Neurology, University of Minnesota, Minneapolis, USA.
Adolfo Ramirez-ZamoraDepartment of Neurology, Shands at University of Florida, University of Florida, Gainesville, USA.ORCID http://orcid.org/0000-0001-9253-3899
Alfonso FasanoEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-5346-0180
Travis HassellDepartment of Neurology, Vanderbilt University Medical Center, Nashville, USA.
Kyle T MitchellDuke University Movement Disorders Center, Duke University, Durham, USA.
Elena MoroGrenoble Alpes University, Division of Neurology, Grenoble Institute of Neuroscience, CHU of Grenoble, Grenoble, France.
Michal GostkowskiCenter for Neurological Restoration, Cleveland Clinic Foundation, Cleveland, USA.
Nagaraja SarangmatOxford University Hospitals NHS Foundation Trust, Oxford, UK.
Helen Bronte-StewartDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, USA.ORCID http://orcid.org/0000-0002-1839-4541
ADAPT-PD Investigators

Funding

Uncovering the neurophysiology of motivation in Parkinson™s disease with implanted adaptive brain stimulationK23NS120037 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LITTLE, SIMON · 2021 to 2024
$809k
NINDS NIH HHS K23 NS120037
6 · The paper itself

Abstract

Adaptive deep brain stimulation (aDBS) is an emerging advancement in DBS technology; however, local field potential (LFP) signal rate detection sufficient for aDBS algorithms and the methods to set-up aDBS have yet to be defined. Here we summarize sensing data and aDBS programming steps associated with the ongoing Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) pivotal trial (NCT04547712). Sixty-eight patients were enrolled with either subthalamic nucleus or globus pallidus internus DBS leads connected to a Medtronic Percept

Identifiers

PMID39289373
PMCPMC11408616

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.