ArticleNature communications2024
Metabolic interdependencies in thermophilic communities are revealed using co-occurrence and complementarity networks.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
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- Rice-crayfish farming mode drives distinct soil properties and ecological assembly of soil microbiome.Microbiology spectrum · 2026Article
- Multiomics reveals postherbivory tea leaves restructure endophytic microbiota to resist disease and boost saccharide metabolism to promote growth.Horticulture research · 2026Article
- A New Framework to Empower Ecosystem Assessment Through the Integration of eDNA Inventories, Graph Theory and Niche Modelling.Ecology letters · 2026Article
- Metabolic interactions drive microbial community succession and functional expression of Nongxiangxing (Strong-flavor) daqu.Journal of advanced research · 2026Article
- The mycobiome, virome and archaeome in gastrointestinal cancers: molecular pathogenesis and therapeutic intervention.Molecular cancer · 2026Review
- Vertical distribution and metabolic diversity of autotrophic microbes in the deep sediment of the challenger deep.Environmental microbiome · 2026Article
- Azolla reshapes rhizosphere microbiomes and nutrient cycling in paddy fields.Environmental microbiome · 2026Article
- Decoding extremophiles: insights from bioinformatics, machine learning, and data-driven approaches.Briefings in bioinformatics · 2026Review
- Community context reshapes microbial proteomes and reduces functional overlap.Nature microbiology · 2026Article
- Seed-microbiome interactions: Mechanistic insights and utilization toward seed performance for sustainable agriculture.Plant communications · 2026Review
- Construction of microecological discrimination models for high-temperature Daqu from different regions.Food chemistry: X · 2026Article
- Cross-domain cooperation drives nutrient acquisition and metabolism in the bark beetle holobiont.The ISME journal · 2026Article
- Microbial synthesis structures organic compound composition in anaerobic digestion.The ISME journal · 2026Article
- Metabolic division of labor drives estuarine-coastal N2O emissions.The ISME journal · 2026Article
- Molecular adaptations and engineering of extremophiles for synthetic biology and biotechnological applications.Frontiers in microbiology · 2026Review
- Mechanisms by stand density regulates soil multifunctionality via soil environment and microbial network topology in aFrontiers in microbiology · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial communities exhibit intricate interactions underpinned by metabolic dependencies. To elucidate these dependencies, we present a workflow utilizing random matrix theory on metagenome-assembled genomes to construct co-occurrence and metabolic complementarity networks. We apply this approach to a temperature gradient hot spring, unraveling the interplay between thermal stress and metabolic cooperation. Our analysis reveals an increase in the frequency of metabolic interactions with rising temperatures. Amino acids, coenzyme A derivatives, and carbohydrates emerge as key exchange metabolites, forming the foundation for syntrophic dependencies, in which commensalistic interactions take a greater proportion than mutualistic ones. These metabolic exchanges are most prevalent between phylogenetically distant species, especially archaea-bacteria collaborations, as a crucial adaptation to harsh environments. Furthermore, we identify a significant positive correlation between basal metabolite exchange and genome size disparity, potentially signifying a means for streamlined genomes to leverage cooperation with metabolically richer partners. This phenomenon is also confirmed by another composting system which has a similar wide range of temperature fluctuations. Our workflow provides a feasible way to decipher the metabolic complementarity mechanisms underlying microbial interactions, and our findings suggested environmental stress regulates the cooperative strategies of thermophiles, while these dependencies have been potentially hardwired into their genomes during co-evolutions.
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