Trial reportBMJ open2024
Prehabilitation for frail patients undergoing hip and knee replacement in the UK: Joint PREP feasibility study for a randomised controlled trial.
Trial report in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Peri-operative protein or amino acid supplementation for total joint arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- 'Prehabilitation Should Adapt to the Person, not the Other Way Around': A Qualitative Study Exploring Stakeholder Perceptions of Prehabilitation for Total Hip and Knee Arthroplasty.Musculoskeletal care · 2026Article
- Multimodal prehabilitation for frail older adults having hip or knee replacement: a qualitative exploratory study of barriers and facilitators.BMC musculoskeletal disorders · 2026Article
- Outcome measures in prehabilitation interventions for total hip and knee arthroplasty: A scoping review.Clinical rehabilitation · 2026Article
- Experiences and Perceptions of Patients Participating in Prehabilitation and Early Rehabilitation for Hip and Knee Arthroplasty: A Systematic Review and Narrative Synthesis of Qualitative Evidence.Patient preference and adherence · 2026Review
- Multicomponent prehabilitation and perioperative care in older persons with frailty referred to planned orthopaedic surgery: A feasibility study.Aging clinical and experimental research · 2025Article
- The Role of Health Psychology in Surgical Prehabilitation: Insights From REST, a Preoperative Sleep Intervention for Total Knee Replacement Patients.Musculoskeletal care · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the feasibility of conducting a randomised controlled trial (RCT) to evaluate a prehabilitation programme for frail patients undergoing total hip replacement (THR) or total knee replacement (TKR).
designRandomised feasibility study with embedded qualitative work.
settingThree National Health Service hospitals.
participantsAdults aged ≥65 years, frail and scheduled for primary THR or TKR.
interventionAppointment with a physiotherapist to individualise a home-based exercise programme. Participants were encouraged to do the home exercises daily for 12 weeks pre-operative and were provided with a daily protein supplement. Participants were supported by six telephone calls over the 12-week intervention period. OUTCOME MEASURES: Eligibility and recruitment rates, intervention adherence, data completion rates of patient-reported outcome measures, retention rates and acceptability of the trial and intervention. Qualitative interviews were conducted with participants and non-participants and analysed using thematic analysis.
resultsBetween December 2022 and August 2023, 411 patients were sent a screening pack. Of the 168 patients who returned a screening questionnaire, 79 were eligible and consented to participate, and 64 were randomised. Of the 33 participants randomised to the intervention, 26 attended the intervention appointment. Eighteen participants (69%) received all six intervention follow-up telephone calls. Nineteen participants (73%) completed an intervention adherence log; 13 (68%) adhered to the exercise programme and 11 (58%) adhered to the protein supplementation. The overall retention rate was 86% (55/64 overall) at 12 weeks. The 12-week follow-up questionnaire was returned by 46 of the 55 participants (84%) who were sent a questionnaire. Interviews with 19 patients found that the trial processes and intervention were generally acceptable, but areas of potential improvements were identified.
conclusionsThis study demonstrated that a larger study is possible and has identified improvements to optimise the design of an RCT. TRIAL REGISTRATION NUMBER: ISRCTN11121506.
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