Evidence map›Paper›PMID 39288798›Full record

ArticleProceedings. Biological sciences2024

Mechanisms of transcriptional regulation in

Naomi A Dyer, Eric R Lucas, Sanjay C Nagi, Daniel P McDermott, Jon H Brenas, Alistair Miles, Chris S Clarkson, Henry D Mawejje, Craig S Wilding, Marc S Halfon and 3 more

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Mechanisms of transcriptional regulation inProceedings. Biological sciences · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Naomi A DyerDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place , Liverpool L3 5QA, UK.ORCID 0000-0001-8218-4605
Eric R LucasDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place , Liverpool L3 5QA, UK.ORCID 0000-0003-3892-1668
Sanjay C NagiDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place , Liverpool L3 5QA, UK.ORCID 0000-0003-1214-8523
Daniel P McDermottDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place , Liverpool L3 5QA, UK.ORCID 0000-0001-7799-0928
Jon H BrenasWellcome Sanger Institute, Wellcome Genome Campus, Hinxton , Cambridge CB10 1SA, UK.ORCID 0000-0001-9395-9365
Alistair MilesWellcome Sanger Institute, Wellcome Genome Campus, Hinxton , Cambridge CB10 1SA, UK.ORCID 0000-0001-9018-4680
Chris S ClarksonWellcome Sanger Institute, Wellcome Genome Campus, Hinxton , Cambridge CB10 1SA, UK.ORCID 0000-0002-8757-1660
Henry D MawejjeInfectious Diseases Research Collaboration (IDRC), Plot 2C Nakasero Hill Road, PO Box 7475 , Kampala, Uganda.ORCID 0000-0003-4348-3682
Craig S WildingSchool of Biological and Environmental Sciences, Liverpool John Moores University, Byrom Street , Liverpool L3 3AF, UK.ORCID 0000-0001-5818-2706
Marc S HalfonDepartment of Biochemistry, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo-State University of New York, 955 Main Street , Buffalo, NY 14203, USA.ORCID 0000-0002-4149-2705
Hasiba AsmaDepartment of Biochemistry, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo-State University of New York, 955 Main Street , Buffalo, NY 14203, USA.ORCID 0000-0002-9304-2685
Eva HeinzDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place , Liverpool L3 5QA, UK.ORCID 0000-0003-4413-3756
Martin J DonnellyDepartment of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place , Liverpool L3 5QA, UK.ORCID 0000-0001-5218-1497

Funding

Genome-based diagnostics for monitoring and evaluation of insecticide resistance in Anopheles gambiaeR01AI116811 · NIAID · TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE · PI Martin James Donnelly · 2016 to 2026
$4.6M
Bill and Melinda Gates FoundationBiotechnology and Biological Sciences Research CouncilBroad Institute of Harvard andDaphne Jackson FellowshipEuropean UnionLiverpool School of Tropical MedicineMalariaGEN Vector ObservatoryMedical Research Council MR/P02520X/1Medical Research Council MR/T001070/1National Institute of Allergy and Infectious Diseases R01-AI116811NIAIDNIAID NIH HHS R01 AI116811Pan-African Mosquito Control AssociationRoyal SocietySanger InstituteThe Liverpool School of Tropical MedicineThe Pan-African Mosquito Control AssociationWellcome Sanger InstituteWellcome Trust
6 · The paper itself

Abstract

Malaria control relies on insecticides targeting the mosquito vector, but this is increasingly compromised by insecticide resistance, which can be achieved by elevated expression of detoxifying enzymes that metabolize the insecticide. In diploid organisms, gene expression is regulated both in

Indexed as

AllelesAnophelesGene Expression RegulationInsecticide ResistanceAnimalsInsecticidesMosquito VectorsInsecticidesallelecis-regulationinsecticideresistancetranscript

Identifiers

PMID39288798
PMCPMC11407855

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.