Evidence map›Paper›PMID 39288505›Full record

ArticleJournal of geriatric oncology2024

Function, cognition, and quality of life among older adults with lung cancer who live alone: A prospective cohort study.

Surbhi Singhal, Louise C Walter, Alexander K Smith, W John Boscardin, Ying Shi, Harvey Jay Cohen, Carolyn J Presley, Lawrence H Kushi, Smith Giri, Allison Magnuson and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Risk factors associated with the co-occurrence of severe pain and sleep disturbance in oncology outpatients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Surbhi SinghalDivision of Hematology/Oncology, Department of Medicine, University of California, Davis, Sacramento, CA, USA.
Louise C WalterDivision of Geriatrics, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Alexander K SmithDivision of Geriatrics, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
W John BoscardinDivision of Geriatrics, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Ying ShiDivision of Geriatrics, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Harvey Jay CohenCenter for the Study of Aging & Human Development and Duke Cancer Institute, Duke University, Durham, NC, USA.
Carolyn J PresleyDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Lawrence H KushiDivision of Research, Kaiser Permanente Northern California, The Permanente Medical Group, Oakland, CA, USA.
Smith GiriDivisions of Hematology/Oncology and Gerontology, Geriatrics, and Palliative Care, The University of Alabama at Birmingham, Birmingham, AL, USA.
Allison MagnusonJames P. Wilmot Cancer Institute, Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Grant R WilliamsDivisions of Hematology/Oncology and Gerontology, Geriatrics, and Palliative Care, The University of Alabama at Birmingham, Birmingham, AL, USA.
Ana I VelazquezDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Howard J LeeDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Lori C SakodaDivision of Research, Kaiser Permanente Northern California, The Permanente Medical Group, Oakland, CA, USA.
Charles P QuesenberryDivision of Research, Kaiser Permanente Northern California, The Permanente Medical Group, Oakland, CA, USA.
Jason R FalveyDepartment of Physical Therapy and Rehabilitation Science, University of Maryland, Baltimore, MD, USA.
Kathleen M Van DykDivision of Geriatric Psychiatry, Department of Psychiatry, University of California, Los Angeles Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
Melisa L WongDivision of Geriatrics, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Division of Research, Kaiser Permanente Northern California, The Permanente Medical Group, Oakland, CA, USA. Electronic address: melisa.wong@kp.org.

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7M
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI CATHLEEN S COLON-EMERIC, Susan Nicole Hastings · 2006 to 2026
$24.6M
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
RESOURCE CENTER FOR AGING RESEARCH IN DIVERSE POPULATIONP30AG015272 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Torsten Brian Neilands · 1997 to 2026
$19.5M
The ENRICH Study: Engaging Community and Municipal Services to Promote High Quality Aging in Place After Hip FractureK76AG074926 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI FALVEY, JASON RAYMOND · 2021 to 2025
$1.4M
Mitigating Cancer-Related Cognitive Dysfunction in Older Adults with Breast CancerK76AG064394 · NIA · UNIVERSITY OF ROCHESTER · PI MAGNUSON, ALLISON MARIAN · 2019 to 2023
$1.3M
Advancing patient-centered decision making in older adults with lung cancer: Incorporating risk of functional decline into treatment discussionsK76AG064431 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WONG, MELISA L · 2019 to 2023
$1.3M
Resiliency among Older Adults Receiving Lung Cancer Treatment: A Supportive Care Intervention StudyK76AG074923 · NIA · OHIO STATE UNIVERSITY · PI PRESLEY, CAROLYN · 2021 to 2025
$1.2M
Mentoring Researchers in Prognosis Research in Alzheimer’s Disease and Related DementiasK24AG068312 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 2020 to 2026
$1.2M
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults with Colorectal Cancer: The M&M StudyK08CA234225 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILLIAMS, GRANT R · 2018 to 2022
$1.0M
NCATS NIH HHS KL2 TR001870NCI NIH HHS K08 CA234225NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA082103NIA NIH HHS K24 AG068312NIA NIH HHS K76 AG064394NIA NIH HHS K76 AG064431NIA NIH HHS K76 AG074923NIA NIH HHS K76 AG074926NIA NIH HHS P30 AG015272NIA NIH HHS P30 AG028716NIA NIH HHS P30 AG044281NIA NIH HHS R03 AG056439NIA NIH HHS R03 AG064374
6 · The paper itself

Abstract

introductionAmong older adults without cancer, living alone is associated with poor health outcomes. However, among older adults with non-small cell lung cancer (NSCLC) who live alone, data on function, cognition, and quality of life (QOL) during systemic treatment remain limited. MATERIALS AND

methodsWe enrolled adults aged ≥65 with advanced NSCLC starting a new chemotherapy, immunotherapy, and/or targeted therapy regimen with non-curative intent. Patients completed geriatric assessments including instrumental activities of daily living (IADL), Montreal Cognitive Assessment, and QOL pretreatment and at 1, 2, 4, and 6 months, or until treatment discontinuation, whichever occurred earlier. We categorized change in IADL, cognition, and QOL as stable/improved, declined with recovery, or declined without recovery using clinically meaningful definitions of change. We used multinomial logistic regression to compare change between patients who lived alone versus with others.

resultsAmong 149 patients, median age was 73; 21% lived alone. Pretreatment IADL, cognition, and QOL scores were similar between older adults who lived alone versus with others. During NSCLC treatment, older adults who lived alone had similar trajectories of function (52% functional decline vs 38%), cognition (43% cognitive decline vs 50%), and QOL (45% QOL decline vs 44%) compared with those who lived with others. In unadjusted analyses, patients who lived alone were more likely to develop functional decline with recovery (reference category: stable/improved function) than those who lived with others (relative risk ratio 4.07, 95% CI 1.14-14.6, p = 0.03). However, this association was not observed after adjusting for age, race, prior NSCLC treatment, current treatment group, and pretreatment geriatric assessment differences. There were no differences in cognitive or QOL trajectories in unadjusted or adjusted analyses. DISCUSSION: Approximately half of older adults with advanced NSCLC who lived alone were able to maintain their function, cognition, and QOL during NSCLC treatment, which was similar to older adults who lived with others. Many older adults with advanced NSCLC who live alone can receive systemic treatment with individualized supportive care.

Indexed as

Activities of Daily LivingCarcinoma, Non-Small-Cell LungCognitionGeriatric AssessmentLung NeoplasmsQuality of LifeAgedAged, 80 and overCognitive DysfunctionFemaleHumansMaleProspective StudiesCognitionFunctionInstrumental activities of daily livingLung cancerOlder adultsQuality of life

Identifiers

PMID39288505
PMCPMC12312441

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.