Evidence map›Paper›PMID 39288179›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Microbial community interactions on a chip.

Duane S Juang, Wren E Wightman, Gabriel L Lozano, Terry D Juang, Layla J Barkal, Jiaquan Yu, Manuel F Garavito, Amanda Hurley, Ophelia S Venturelli, Jo Handelsman and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Duane S JuangDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-6832-4277
Wren E WightmanDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0001-8468-470X
Gabriel L LozanoWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715.ORCID 0000-0001-9327-4470
Terry D JuangDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706.
Layla J BarkalDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-4734-7197
Jiaquan YuDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706.
Manuel F GaravitoWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715.
Amanda HurleyWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715.ORCID 0000-0002-8322-4143
Ophelia S VenturelliDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0003-2200-1963
Jo HandelsmanWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715.
David J BeebeDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-0415-9006

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Elucidating the molecular and ecological design principles of stability and assembly of the human gut microbiotaR35GM124774 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Ophelia Venturelli · 2017 to 2026
$2.9M
Model-guided design of next-generation bacterial therapeutics to treat cardiovascular diseaseR01EB030340 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI REY, FEDERICO E, ROMERO, PHILIP ANTHONY · 2020 to 2023
$2.8M
HHS | NIH (NIH) P30CA014520NCI NIH HHS P30 CA014520NIBIB NIH HHS R01 EB030340NIGMS NIH HHS R35 GM124774State of Wisconsin N/AU.S. Army Research Laboratory W911NF1910269UW | Office of the Vice Chancellor for Research and Graduate Education, University of Wisconsin-Madison (VCRGE, UW) N/A
6 · The paper itself

Abstract

Multispecies microbial communities drive most ecosystems on Earth. Chemical and biological interactions within these communities can affect the survival of individual members and the entire community. However, the prohibitively high number of possible interactions within a microbial community has made the characterization of factors that influence community development challenging. Here, we report a Microbial Community Interaction (µCI) device to advance the systematic study of chemical and biological interactions within a microbial community. The µCI creates a combinatorial landscape made up of an array of triangular wells interconnected with circular wells, which each contains either a different chemical or microbial strain, generating chemical gradients and revealing biological interactions.

Indexed as

Bacillus cereusAnti-Bacterial AgentsGentamicinsGreen Fluorescent ProteinsLab-On-A-Chip DevicesMicrobial InteractionsMicrobiotaRhizosphereVancomycinAnti-Bacterial AgentsGentamicinsGreen Fluorescent ProteinsVancomycinantibioticsfabricated microbial ecosystemsmicrobial communitiesmicrobial interactionsmicrofluidics

Identifiers

PMID39288179
PMCPMC11441501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.