Evidence map›Paper›PMID 39287911›Full record

ArticleMolecular biology reports2024

Intervertebral disc degenerative disease in South Africa: a case-control analysis of selected gene variants.

Keenau Pearce, Stephanie Less, Adriaan W Liebenberg, Mongi Benjeddou

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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Keenau PearcePrecision Medicine Unit, Department of Biotechnology, University of the Western Cape, Cape Town, South Africa. kpearce@uwc.ac.za.
Stephanie LessPrecision Medicine Unit, Department of Biotechnology, University of the Western Cape, Cape Town, South Africa.
Adriaan W LiebenbergHealth Collective, Panorama Healthcare Building, Cape Town, South Africa.
Mongi BenjeddouPrecision Medicine Unit, Department of Biotechnology, University of the Western Cape, Cape Town, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntervertebral disc (IVD) degenerative disease is a multifactorial disease for which genetics plays an integral role. Several genes, and their variants, associated with the development and progression of IVD degenerative disease have been identified. While several studies have investigated these genes in Asian and European populations, no available evidence exists for the South African population. Therefore, this study aimed to investigate these parameters. METHODS AND

resultsBiological samples were collected in the form of buccal swabs from patients and DNA was extracted using a standard salt-lysis protocol. DNA purity and quantity was assessed by spectrophotometry, and subsequent genotyping was performed using the MassARRAY

conclusionTo the best of our knowledge, this study represents the first of its kind to investigate the association of gene variants associated with IVD degenerative disease within the South African population. This study has shown that 5 of these gene variants were significantly associated with the presence of IVD degenerative disease, reflecting their integral roles in development and possible progression of the disease.

Indexed as

Genetic Predisposition to DiseaseIntervertebral Disc DegenerationPolymorphism, Single NucleotideADAMTS5 ProteinAdultAgedCase-Control StudiesFemaleGenetic Association StudiesGenotypeGrowth Differentiation Factor 5HumansInterleukin-1alphaMaleMatrix Metalloproteinase 3Middle AgedADAMTS5 ProteinADAMTS5 protein, humanGDF5 protein, humanGrowth Differentiation Factor 5IL1A protein, humanInterleukin-1alphaMatrix Metalloproteinase 3MMP3 protein, humanAlleleGenotypeIntervertebral disc degenerative diseaseSingle nucleotide polymorphismSouth Africa

Identifiers

PMID39287911
PMCPMC11408536

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