Evidence map›Paper›PMID 39287887›Full record

ArticleMolecular imaging and biology2024

Radioimaging Foam Cells Infiltrating Atherosclerotic Plaques in Mice Using

Michi Izawa, Hidekazu Kawashima, Yui Okuno, Junna Nakaya, Mayuko Takeda, Koki Harada, Yuri Yamada, Kaneyasu Nishimura, Keiichi Ishihara, Satoshi Akiba and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michi Izawa *Joint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan.
Hidekazu Kawashima *Radioisotope Research Center, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan. kawap@mb.kyoto-phu.ac.jp.
Yui OkunoJoint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan.
Junna NakayaJoint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan.
Mayuko TakedaJoint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan.
Koki HaradaJoint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan.
Yuri YamadaJoint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan.
Kaneyasu NishimuraJoint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan.
Keiichi IshiharaLaboratory of Pathological Biochemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan.
Satoshi AkibaLaboratory of Pathological Biochemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan.
Kazuyuki TakataJoint Research Laboratory, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto, 607-8414, Japan. kaz@mb.kyoto-phu.ac.jp.ORCID 0000-0001-5332-1279

Funding

Japan Society for the Promotion of Science 20H03569Japan Society for the Promotion of Science 21K06502Kyoto Pharmaceutical University Fund for the Collaborative ResearchMinistry of Education, Culture, Sports, Science and Technology Private University Research Branding Project
6 · The paper itself

Abstract

Bioimaging such as magnetic resonance is used to monitor atherosclerotic plaques consisting of foam cells, which are derived from macrophages that have ingested oxidized low-density lipoprotein (oxLDL). However, the current bioimaging techniques are not highly specific and sensitive in detecting foam cells, calling for the development of higher precision foam cell detection probes. Here, we investigated the utility of iodine-125-labeled oxLDL (

Indexed as

Foam CellsIodine RadioisotopesLipoproteins, LDLMice, Inbred C57BLPlaque, AtheroscleroticAnimalsAutoradiographyDisease Models, AnimalMacrophagesMaleMicePhagocytosisRadioactive TracersIodine-125Iodine RadioisotopesLipoproteins, LDLoxidized low density lipoproteinRadioactive TracersAtherosclerosisBioimagingDiagnosisDiIFoam cellsIodine-125MacrophagesMiceOxLDLSPECT/CT

Identifiers

PMID39287887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.