Evidence map›Paper›PMID 39287823›Full record

ArticleVirchows Archiv : an international journal of pathology2024

Acceptance of emerging renal oncocytic neoplasms: a survey of urologic pathologists.

Sambit K Mohanty, Anandi Lobo, Shilpy Jha, Ankur R Sangoi, Mahmut Akgul, Kiril Trpkov, Ondrej Hes, Rohit Mehra, Michelle S Hirsch, Holger Moch and 55 more

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Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

65 authors.

Sambit K MohantyDepartment of Pathology, Advanced Medical Research Institute Hospital, Kolkata, India.
Anandi LoboDepartment of Pathology, Kapoor Center of Urology and Pathology, Raipur, India.
Shilpy JhaDepartment of Pathology, Advanced Medical Research Institute Hospital, Kolkata, India.
Ankur R SangoiDepartment of Pathology, El Camino Hospital, Mountain View, USA.
Mahmut AkgulDepartment of Pathology, Albany Medical Centre, Albany, USA.
Kiril TrpkovDepartment of Pathology, University of Calgary, Calgary, Canada.
Ondrej HesDepartment of Pathology, Bioptika Laborator S.R.O, Pilsen, Czech Republic.
Rohit MehraDepartment of Pathology, University of Michigan, Ann Arbor, USA.
Michelle S HirschDepartment of Pathology, Brigham and Women's Hospital, Boston, USA.
Holger MochDepartment of Pathology, University Hospital, Zurich, Switzerland.
Steven C SmithDepartment of Pathology, Virginia Commonwealth University School of Medicine, Richmond, USA.
Rajal B ShahDepartment of Pathology, UT Southwestern Medical Center, Dallas, USA.
Liang ChengDepartment of Pathology, Brown University, Providence, USA.
Mahul B AminDepartment of Pathology, The University of Tennessee Health Science Center, Memphis, USA.
Jonathan I EpsteinIMP Pathology, Garden City, USA.
Anil V ParwaniDepartment of Pathology, Ohio State University, Columbus, USA.
Brett DelahuntDepartment of Pathology, Wellington School/Medicine, Wellington, New Zealand.
Sangeeta DesaiDepartment of Pathology, Tata Memorial Hospital, Mumbai, India.
Christopher G PrzybycinDepartment of Pathology, Cleveland Clinic, Cleveland, USA.
Claudia ManiniDepartment of Pathology, University of Turin, Turin, Italy.
Daniel J LuthringerDepartment of Pathology, Cedars-Sinai Medical Center, Los Angeles, USA.
Deepika SirohiDepartment of Pathology, University of Utah/ARUP, Salt Lake City, USA.
Deepika JainDepartment of Pathology, Core Diagnostics, Gurgaon, India.
Divya MidhaDepartment of Pathology, Tata Medical Center, Kolkata, India.
Ekta JainDepartment of Pathology, Core Diagnostics, Gurgaon, India.
Fiona MacleanDepartment of Pathology, Douglass Hanly Moir Pathology, Sydney, Australia.
Giovanna A GiannicoDepartment of Pathology, Vanderbilt University Medical Center, Nashville, USA.
Gladell P PanerDepartment of Pathology, University of Chicago, Chicago, USA.
Guido MartignoniDepartment of Pathology, University of Verona, Verona, Italy.
Hikmat A Al-AhmadieDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
Jesse McKenneyDepartment of Pathology, Cleveland Clinic, Cleveland, USA.
John R SrigleyDepartment of Pathology, Trillium Health Partners, Credit Valley Hospital, Mississauga, Canada.
Jose Ignacio LopezDepartment of Pathology, Cruces University Hospital, Barakaldo, Spain.
L Priya KunjuDepartment of Pathology, University of Michigan, Ann Arbor, USA.
Lisa BrowningDepartment of Pathology, Oxford University Hospital NHS Foundation Trust, Oxford, UK.
Manju AronDepartment of Pathology, Keck School of Medicine of USC, Los Angeles, USA.
Maria M PickenDepartment of Pathology, Loyola University Medical Center, Maywood, USA.
Maria TretiakovaDepartment of Pathology, University of Washington, Seattle, USA.
Ming ZhouDepartment of Pathology, Tufts University School of Medicine, Boston, USA.
Mukund SableDepartment of Pathology, All India Institute of Medical Sciences, Bhubaneswar, India.
Naoto KurodaDepartment of Pathology, Kochi Red Cross Hospital, Kochi City, Kochi, Japan.
Niharika PattnaikDepartment of Pathology, Advanced Medical Research Institute Hospital, Kolkata, India.
Nilesh S GuptaDepartment of Pathology, Henry Ford Health System, Detroit, USA.
Priya RaoDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA.
Samson W FineDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
Pritinanda MishraDepartment of Pathology, All India Institute of Medical Sciences, Bhubaneswar, India.
Amit K AdhyaDepartment of Pathology, All India Institute of Medical Sciences, Bhubaneswar, India.
Bijal N KulkarniDepartment of Pathology, Kokilaben Ambani Hospital, Mumbai, India.
Mallika DixitDepartment of Pathology, Core Diagnostics, Gurgaon, India.
Manas R BaisakhDepartment of Pathology, Apollo Hospitals Bhubaneshwar, Bhubaneswar, India.
Samriti AroraDepartment of Pathology, Core Diagnostics, Gurgaon, India.
Sankalp SanchetiDepartment of Pathology, Homi Bhabha Cancer Center, Visakhapatnam, India.
Santosh MenonDepartment of Pathology, Tata Memorial Hospital, Mumbai, India.
Sara E WobkerDepartment of Pathology, The University of North Carolina at Chapel Hill, Chapel Hill, USA.
Satish K TickooDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
Seema KaushalDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Shailesh SoniDepartment of Pathology, Muljibhai Patel Urological Hospital, Nadiad, India.
Shivani KandukuriDepartment of Pathology, Keck School of Medicine of USC, Los Angeles, USA.
Shivani SharmaDepartment of Pathology, Core Diagnostics, Gurgaon, India.
Suvradeep MitraDepartment of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Victor E ReuterDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
Vipra MalikDepartment of Pathology, Core Diagnostics, Gurgaon, India.
Vishal RaoDepartment of Pathology, Basavatakaram Indo-American Cancer Hospital and Research Institute, Hyderabad, India.
Ying-Bei ChenDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
Sean R WilliamsonDepartment of Pathology, Cleveland Clinic, Cleveland, USA. willias73@ccf.org.ORCID http://orcid.org/0000-0002-3898-1460

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Oncocytic renal neoplasms are a major source of diagnostic challenge in genitourinary pathology; however, they are typically nonaggressive in general, raising the question of whether distinguishing different subtypes, including emerging entities, is necessary. Emerging entities recently described include eosinophilic solid and cystic renal cell carcinoma (ESC RCC), low-grade oncocytic tumor (LOT), eosinophilic vacuolated tumor (EVT), and papillary renal neoplasm with reverse polarity (PRNRP). A survey was shared among 65 urologic pathologists using SurveyMonkey.com (Survey Monkey, Santa Clara, CA, USA). De-identified and anonymized respondent data were analyzed. Sixty-three participants completed the survey and contributed to the study. Participants were from Asia (n = 21; 35%), North America (n = 31; 52%), Europe (n = 6; 10%), and Australia (n = 2; 3%). Half encounter oncocytic renal neoplasms that are difficult to classify monthly or more frequently. Most (70%) indicated that there is enough evidence to consider ESC RCC as a distinct entity now, whereas there was less certainty for LOT (27%), EVT (29%), and PRNRP (37%). However, when combining the responses for sufficient evidence currently and likely in the future, LOT and EVT yielded > 70% and > 60% for PRNRP. Most (60%) would not render an outright diagnosis of oncocytoma on needle core biopsy. There was a dichotomy in the routine use of immunohistochemistry (IHC) in the evaluation of oncocytoma (yes = 52%; no = 48%). The most utilized IHC markers included keratin 7 and 20, KIT, AMACR, PAX8, CA9, melan A, succinate dehydrogenase (SDH)B, and fumarate hydratase (FH). Genetic techniques used included TSC1/TSC2/MTOR (67%) or TFE3 (74%) genes and pathways; however, the majority reported using these very rarely. Only 40% have encountered low-grade oncocytic renal neoplasms that are deficient for FH. Increasing experience with the spectrum of oncocytic renal neoplasms will likely yield further insights into the most appropriate work-up, classification, and clinical management for these entities.

Indexed as

Adenoma, OxyphilicCarcinoma, Renal CellKidney NeoplasmsPathologistsBiomarkers, TumorHumansSurveys and QuestionnairesBiomarkers, TumorEmergingEosinophilicOncocyticRenal neoplasmsUropathologists

Identifiers

PMID39287823
PMCPMC11564393

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.