Evidence map›Paper›PMID 39287790›Full record

ArticleMikrochimica acta2024

Bilayer MOF nanomachine for precision breast cancer cell fluorescent imaging and therapy.

Yijun Zhao, Guizhen Hu, Zhaoge Li, Yamin Nie, Yonghong Li, Yanmei Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yijun ZhaoHenan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China.
Guizhen HuHenan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China.
Zhaoge LiHenan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China.
Yamin NieHenan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China.
Yonghong LiHenan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China.
Yanmei ZhouHenan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, 475004, China. zhouyanmei@henu.edu.cn.

Funding

National Natural Science Foundation of China 21978069National Natural Science Foundation of China 22278112
6 · The paper itself

Abstract

A bilayer MOF reporter (ZIF-67@FAM-mRNA@ZIF-8) was synthesized, and the ZIF-67 was used as a carrier and fluorescent quencher to connect the FAM reporter through electrostatic adsorption and coordination effect. The ZIF-8 covering the outer layer can improve the stability of the probe and cell permeability, which helps the FAM reporter effectively release. After entering the cancer cells, the acidic environment in the cells induced the decomposition of ZIF-8. The excess ATP in the tumor cells competitively binds ZIF-67, causing the FAM reporter to shed and restore fluorescence. The shed FAM reporter was specifically bound to the overexpressed miRNA-21 in breast cancer cells to achieve fluorescence imaging and therapy of breast cancer. The results of specific imaging and apoptosis experiments of breast cancer cells indicate that bilayer MOF nanomachine provides an effective nanotherapy platform for accurate fluorescence imaging.

Indexed as

Breast NeoplasmsFluorescent DyesMetal-Organic FrameworksMicroRNAsOptical ImagingApoptosisCell Line, TumorFemaleHumansImidazolesMCF-7 CellsFluorescent DyesImidazolesMetal-Organic FrameworksMicroRNAsMIRN21 microRNA, humanZIF-8 metal-organic frameworkATPBreast cancerFluorescence imagingMetal–organic framework

Identifiers

PMID39287790

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.