Evidence map›Paper›PMID 39287665›Full record

ArticleJournal of the American Chemical Society2024

A Bioorthogonal Precision Tool for Human

Yu Liu, Ganka Bineva-Todd, Richard W Meek, Laura Mazo, Beatriz Piniello, Olga Moroz, Sean A Burnap, Nadima Begum, André Ohara, Chloe Roustan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Iterative Bump-and-Hole Engineering Creates a Bioorthogonal Reporter forJournal of the American Chemical Society · 2026
    Article
  3. Article
  4. Iterative Bump-and-hole engineering creates a bioorthogonal reporter forbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yu LiuDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.
Ganka Bineva-ToddChemical Glycobiology Laboratory, The Francis Crick Institute, London NW1 1AT, U.K.
Richard W MeekYork Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K.
Laura MazoDepartament de Química Inorgànica i Orgànica (Secció de Química Orgànica) and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.
Beatriz PinielloDepartament de Química Inorgànica i Orgànica (Secció de Química Orgànica) and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.ORCID 0000-0001-5557-3146
Olga MorozYork Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K.
Sean A BurnapDepartment of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.
Nadima BegumDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.
André OharaDepartment of Chemical Engineering and Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, U.K.
Chloe RoustanStructural Biology Science Technology Platform, The Francis Crick Institute, London NW1 1AT, U.K.
Sara TomitaDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.
Svend KjaerStructural Biology Science Technology Platform, The Francis Crick Institute, London NW1 1AT, U.K.
Karen PolizziDepartment of Chemical Engineering and Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, U.K.ORCID 0000-0001-5435-2667
Weston B StruweDepartment of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.ORCID 0000-0003-0594-226X
Carme RoviraDepartament de Química Inorgànica i Orgànica (Secció de Química Orgànica) and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.ORCID 0000-0003-1477-5010
Gideon J DaviesYork Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, U.K.ORCID 0000-0002-7343-776X
Benjamin SchumannDepartment of Chemistry, Imperial College London, London W12 0BZ, U.K.ORCID 0000-0001-5504-0147

Funding

ZINC DEFICIENCY &PROTEIN EXPRESSION IN RAT OLFACTORY BULBSP41RR005351 · NCRR · UNIVERSITY OF GEORGIA (UGA) · PI AZADI, PARASTOO · 1989 to 2011
$18.4M
Medical Research CouncilNCRR NIH HHS P41 RR005351Wellcome Trust CC2127
6 · The paper itself

Abstract

Correct elaboration of N-linked glycans in the secretory pathway of human cells is essential in physiology. Early N-glycan biosynthesis follows an assembly line principle before undergoing crucial elaboration points that feature the sequential incorporation of the sugar

Indexed as

N-AcetylglucosaminyltransferasesHumansModels, MolecularProtein EngineeringSubstrate SpecificityMgat5 protein, humanN-Acetylglucosaminyltransferases

Identifiers

PMID39287665
PMCPMC11450819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.