Evidence map›Paper›PMID 39287621›Full record

ArticleeLife2024

Structure and evolution of alanine/serine decarboxylases and the engineering of theanine production.

Hao Wang, Biying Zhu, Siming Qiao, Chunxia Dong, Xiaochun Wan, Weimin Gong, Zhaoliang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hao Wang *Department of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID https://orcid.org/0009-0003-8119-9882
Biying Zhu *State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.ORCID https://orcid.org/0009-0000-9652-7787
Siming QiaoState Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
Chunxia DongState Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
Xiaochun WanState Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
Weimin GongDepartment of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID https://orcid.org/0000-0002-6723-1298
Zhaoliang ZhangState Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.ORCID https://orcid.org/0000-0001-6615-1598

Funding

Ministry of Science and Technology of the People's Republic of China 2019YFA0904100Ministry of Science and Technology of the People's Republic of China 2022YFF1003103Ministry of Science and Technology of the People's Republic of China 32072624Ministry of Science and Technology of the People's Republic of China T2221005
6 · The paper itself

Abstract

Ethylamine (EA), the precursor of theanine biosynthesis, is synthesized from alanine decarboxylation by alanine decarboxylase (AlaDC) in tea plants. AlaDC evolves from serine decarboxylase (SerDC) through neofunctionalization and has lower catalytic activity. However, lacking structure information hinders the understanding of the evolution of substrate specificity and catalytic activity. In this study, we solved the X-ray crystal structures of AlaDC from

Indexed as

ArabidopsisCamellia sinensisCarboxy-LyasesGlutamatesArabidopsis ProteinsCrystallography, X-RayEvolution, MolecularModels, MolecularPlant ProteinsProtein ConformationSubstrate SpecificityArabidopsis ProteinsCarboxy-LyasesGlutamatesPlant Proteinstheaninealanine decarboxylaseA. thalianabiochemistryCamellia sinensischemical biologyplant biologyserine decarboxylasesubstrate specificitytheanine

Identifiers

PMID39287621
PMCPMC11407765

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.