Evidence map›Paper›PMID 39287599›Full record

SynthesisWomen's health (London, England)

Pregnancy outcomes in renal transplant recipients: A systematic review and meta-analysis.

Muhammad Saqlain Mustafa, Amber Noorani, Aniqa Abdul Rasool, Fatema Ali Asgar Tashrifwala, Shubha Jayaram, Sandesh Raja, Fatima Jawed, Muhammad Usama Siddiq, Sowmya Govindanahalli Shivappa, Ishaque Hameed and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Women's health (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Muhammad Saqlain MustafaDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.ORCID 0000-0002-3067-3543
Amber NooraniDepartment of Biochemistry, Jinnah Sindh Medical University, Karachi, Pakistan.ORCID 0000-0001-6970-9227
Aniqa Abdul RasoolDepartment of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.ORCID 0000-0002-8645-9669
Fatema Ali Asgar TashrifwalaStamford Hospital, Stamford, CT, USA.ORCID 0000-0002-7537-9719
Shubha JayaramDepartment of Biochemistry, Mysore Medical College and Research Institute, Mysore, Karnataka, India.
Sandesh RajaDepartment of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Fatima JawedDepartment of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Muhammad Usama SiddiqDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Sowmya Govindanahalli ShivappaDepartment of Microbiology, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
Ishaque HameedDepartment of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Sriharsha DadanaDepartment of Hospital Medicine, Cheyenne Regional Medical Center, Cheyenne, WY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplantation is a superior treatment for end-stage renal disease (ESRD), compared with hemodialysis, offering better quality of life and birth outcomes in women with ESRD and lower fertility rates.

objectivesTo investigate the pregnancy, maternal, fetal, and graft outcomes following kidney transplantation in women with ESRD and evaluate the improvements in quality of life and associated risks.

designA systematic review and meta-analysis performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Meta-analysis of Observational Studies in Epidemiology guidelines. DATA SOURCES AND

methodsA thorough search of multiple databases, including PubMed, Embase, Scopus, ATC abstracts, and Cochrane Central Register of Controlled Trials, was conducted to identify studies that analyzed pregnancy outcomes in kidney transplant patients. The search was conducted from the inception of each database to January 2023.

resultsThe study reviewed 109 studies that evaluated 7708 pregnancies in 5107 women who had undergone renal transplantation. Of these, 78.48% resulted in live births, 9.68% had induced abortion, and 68.67% had a cesarean section. Miscarriage occurred in 12.54%, preeclampsia in 20.87%, pregnancy-induced hypertension in 24.30%, gestational diabetes in 5.08%, and preterm delivery in 45.30% of cases. Of the 853 recipients, 123 had graft loss after pregnancy and 8.06% suffered acute rejection.

conclusionPregnancy after kidney transplantation is associated with risks for mother and fetus; however, live births are still possible. In addition, there are reduced overall risks of stillbirths, miscarriages, neonatal deaths, and gestational diabetes. REGISTRATION: PROSPERO (CRD42024541659).

Indexed as

Kidney Failure, ChronicKidney TransplantationPregnancy ComplicationsPregnancy OutcomeFemaleHumansPregnancyTransplant Recipientsgraft outcomeslive birthsneonatal mortalitypreeclampsiapregnancyrenal transplant

Identifiers

PMID39287599
PMCPMC11418342

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.