ArticleRadiology2024
Progression of Bone Marrow Lesions and the Development of Knee Osteoarthritis: Osteoarthritis Initiative Data.
Abstract read
In one paragraph
Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Beyond Cartilage Regeneration: Targeting the Subchondral Bone with Extracorporeal Shock Wave Therapy and Regenerative Medicine in Knee Osteoarthritis.Bioengineering (Basel, Switzerland) · 2026Review
- Assessing bone microstructure and density with photon-counting CT: emerging applications and challenges.Skeletal radiology · 2026Review
- Multi-label Ensemble Model for Knee Joint Anatomy and Lesion Segmentation: Segmentation of Clinical Images With Ensembling, Morphology, and Attention (SCEMA).Magnetic resonance in medicine · 2026Article
- Validation of an AI-based automated Knee Inflammation MRI Scoring System for assessing bone marrow lesions.EULAR rheumatology open · 2026Article
- Clinical validation of fully automated (peri-)articular tissue analysis for assessing osteoarthritis progression: A narrative review.Osteoarthritis and cartilage open · 2026Review
- Intra-articular and intra-osseous expanded adipose-derived stromal cell injections for knee osteoarthritis-related bone marrow lesions yield promising outcomes: Preliminary results in 16 athletes.Journal of experimental orthopaedics · 2026Article
- Bone Marrow Edema and Tyrosine Kinase Inhibitors Treatment in Chronic Myeloid Leukemia.Diagnostics (Basel, Switzerland) · 2025Article
- Subchondral Phosphate Injection During Hip Arthroscopy Safely Treats Acetabular Bone Marrow Lesions in Early Osteoarthritis.Journal of clinical medicine · 2025Article
- Single-cell sequencing reveals a senescent immune landscape in bone marrow lesions inducing articular cartilage damage in osteoarthritis.Bone research · 2025Article
- Commentary to: recent topics in musculoskeletal imaging focused on clinical applications of AI: how should radiologists approach and use AI?La Radiologia medica · 2025Article
- Arthroscopic-Assisted Management of Subchondral Bone Marrow Lesions of the Knee.Arthroscopy techniques · 2025Article
- The 18th international workshop on osteoarthritis imaging. Structure and pain: Where are we today?Osteoarthritis imaging · 2025Review
- Statin use and longitudinal bone marrow lesion burden: analysis of knees without osteoarthritis from the Osteoarthritis Initiative study.Skeletal radiology · 2025Article
- Imaging of osteoarthritis-related bone marrow lesions in clinical trials.Osteoarthritis imaging · 2025Article
Corrections and comments
- Commented on by
Authors and funding
9 authors.
Kamyar MoradiFrom the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (K.M., H.A.I., S.D.); Tehran University of Medical Sciences School of Medicine, Tehran, Iran (S. Mohammadi, S. Momtazmanesh); Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Mass (F.W.R., A.G.); Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.W.R.); West Virginia University School of Medicine, Morgantown, WV (Q.H.); Department of Rheumatology, University of Sydney, Camperdown, Australia (D.J.H.); and Royal North Shore Hospital, St. Leonards, Sydney, Australia (D.J.H.).ORCID 0000-0002-8663-1190
Soheil MohammadiFrom the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (K.M., H.A.I., S.D.); Tehran University of Medical Sciences School of Medicine, Tehran, Iran (S. Mohammadi, S. Momtazmanesh); Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Mass (F.W.R., A.G.); Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.W.R.); West Virginia University School of Medicine, Morgantown, WV (Q.H.); Department of Rheumatology, University of Sydney, Camperdown, Australia (D.J.H.); and Royal North Shore Hospital, St. Leonards, Sydney, Australia (D.J.H.).ORCID 0000-0003-0616-1780
Frank W RoemerFrom the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (K.M., H.A.I., S.D.); Tehran University of Medical Sciences School of Medicine, Tehran, Iran (S. Mohammadi, S. Momtazmanesh); Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Mass (F.W.R., A.G.); Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.W.R.); West Virginia University School of Medicine, Morgantown, WV (Q.H.); Department of Rheumatology, University of Sydney, Camperdown, Australia (D.J.H.); and Royal North Shore Hospital, St. Leonards, Sydney, Australia (D.J.H.).ORCID 0000-0001-9238-7350
Sara MomtazmaneshFrom the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (K.M., H.A.I., S.D.); Tehran University of Medical Sciences School of Medicine, Tehran, Iran (S. Mohammadi, S. Momtazmanesh); Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Mass (F.W.R., A.G.); Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.W.R.); West Virginia University School of Medicine, Morgantown, WV (Q.H.); Department of Rheumatology, University of Sydney, Camperdown, Australia (D.J.H.); and Royal North Shore Hospital, St. Leonards, Sydney, Australia (D.J.H.).ORCID 0000-0002-3946-1854
Quincy HathawayFrom the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (K.M., H.A.I., S.D.); Tehran University of Medical Sciences School of Medicine, Tehran, Iran (S. Mohammadi, S. Momtazmanesh); Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Mass (F.W.R., A.G.); Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.W.R.); West Virginia University School of Medicine, Morgantown, WV (Q.H.); Department of Rheumatology, University of Sydney, Camperdown, Australia (D.J.H.); and Royal North Shore Hospital, St. Leonards, Sydney, Australia (D.J.H.).ORCID 0000-0001-8226-2319
Hamza Ahmed IbadFrom the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (K.M., H.A.I., S.D.); Tehran University of Medical Sciences School of Medicine, Tehran, Iran (S. Mohammadi, S. Momtazmanesh); Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Mass (F.W.R., A.G.); Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.W.R.); West Virginia University School of Medicine, Morgantown, WV (Q.H.); Department of Rheumatology, University of Sydney, Camperdown, Australia (D.J.H.); and Royal North Shore Hospital, St. Leonards, Sydney, Australia (D.J.H.).ORCID 0000-0003-1557-9484
David J HunterFrom the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (K.M., H.A.I., S.D.); Tehran University of Medical Sciences School of Medicine, Tehran, Iran (S. Mohammadi, S. Momtazmanesh); Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Mass (F.W.R., A.G.); Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.W.R.); West Virginia University School of Medicine, Morgantown, WV (Q.H.); Department of Rheumatology, University of Sydney, Camperdown, Australia (D.J.H.); and Royal North Shore Hospital, St. Leonards, Sydney, Australia (D.J.H.).ORCID 0000-0003-3197-752X
Ali Guermazi *From the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (K.M., H.A.I., S.D.); Tehran University of Medical Sciences School of Medicine, Tehran, Iran (S. Mohammadi, S. Momtazmanesh); Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Mass (F.W.R., A.G.); Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.W.R.); West Virginia University School of Medicine, Morgantown, WV (Q.H.); Department of Rheumatology, University of Sydney, Camperdown, Australia (D.J.H.); and Royal North Shore Hospital, St. Leonards, Sydney, Australia (D.J.H.).ORCID 0000-0002-9374-8266
Shadpour Demehri *From the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (K.M., H.A.I., S.D.); Tehran University of Medical Sciences School of Medicine, Tehran, Iran (S. Mohammadi, S. Momtazmanesh); Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Mass (F.W.R., A.G.); Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.W.R.); West Virginia University School of Medicine, Morgantown, WV (Q.H.); Department of Rheumatology, University of Sydney, Camperdown, Australia (D.J.H.); and Royal North Shore Hospital, St. Leonards, Sydney, Australia (D.J.H.).ORCID 0000-0001-5991-5924
Funding
Skeleton and Joint Degeneration with AgingP01AG066603 · NIA · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2021 to 2025
$9.2MEffect of statin intake on Non-traumatic Generalized Knee OsteoarthritisR01AR079620 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI DEMEHRI, SHADPOUR · 2021 to 2025
$1.8MNIAMS NIH HHS R01 AR079620NIA NIH HHS P01 AG066603
Abstract
Background Bone marrow lesions (BMLs) are a known risk factor for incident knee osteoarthritis (OA), and deep learning (DL) methods can assist in automated segmentation and risk prediction. Purpose To develop and validate a DL model for quantifying tibiofemoral BML volume on MRI scans in knees without radiographic OA and to assess the association between longitudinal BML changes and incident knee OA. Materials and Methods This retrospective study included knee MRI scans from the Osteoarthritis Initiative prospective cohort (February 2004-October 2015). The DL model, developed between August and October 2023, segmented the tibiofemoral joint into 10 subregions and measured BML volume in each subregion. Baseline and 4-year follow-up MRI scans were analyzed. Knees without OA at baseline were categorized into three groups based on 4-year BML volume changes: BML-free, BML regression, and BML progression. The risk of developing radiographic and symptomatic OA over 9 years was compared among these groups. Results Included were 3869 non-OA knees in 2430 participants (mean age, 59.5 years ± 9.0 [SD]; female-to-male ratio, 1.3:1). At 4-year follow-up, 2216 knees remained BML-free, 1106 showed an increase in BML volume, and 547 showed a decrease in BML volume. BML progression was associated with a higher risk of developing radiographic knee OA compared with remaining BML-free (hazard ratio [HR] = 3.0;
Indexed as
Bone Marrow DiseasesDisease ProgressionOsteoarthritis, KneeAgedBone MarrowDeep LearningFemaleHumansKnee JointMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRetrospective StudiesRisk Factors
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.