Evidence map›Paper›PMID 39287436›Full record

ArticlemBio2024

DivIVA controls the dynamics of septum splitting and cell elongation in

Jennyfer Trouve, André Zapun, Laure Bellard, Dimitri Juillot, Anais Pelletier, Celine Freton, Morgane Baudoin, Rut Carballido-Lopez, Nathalie Campo, Yung-Sing Wong and 2 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Defining the order of assembly of theJournal of bacteriology · 2026
    Article
  2. Review
  3. [Advances in the Regulation of Protein Phosphorylation in Streptococcal Cell Wall Synthesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  4. Defining the order of assembly of thebioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. How do spherical bacteria regulate cell division?Biochemical Society transactions · 2025
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jennyfer TrouveUniversité Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
André ZapunUniversité Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
Laure BellardUniversité Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
Dimitri JuillotUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.
Anais PelletierMolecular Microbiology and Structural Biochemistry (MMSB), CNRS, Université Lyon 1, UMR 5086, Lyon, France.
Celine FretonMolecular Microbiology and Structural Biochemistry (MMSB), CNRS, Université Lyon 1, UMR 5086, Lyon, France.
Morgane BaudoinUniversité Grenoble Alpes, CNRS, DPM, Grenoble, France.
Rut Carballido-LopezUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.ORCID 0000-0001-9383-8811
Nathalie CampoLaboratoire de Microbiologie et Génétique Moléculaires, UMR 5100, Centre de Biologie Intégrative, Centre National de la Recherche Scientifique, Toulouse, France.
Yung-Sing WongUniversité Grenoble Alpes, CNRS, DPM, Grenoble, France.
Christophe GrangeasseMolecular Microbiology and Structural Biochemistry (MMSB), CNRS, Université Lyon 1, UMR 5086, Lyon, France.
Cecile MorlotUniversité Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.ORCID 0000-0002-9295-1035

Funding

Agence Nationale de la Recherche (ANR) ANR-16-CE11-0016Agence Nationale de la Recherche (ANR) ANR-17-CE13-0031Agence Nationale de la Recherche (ANR) ANR-19-CE15-0011Agence Nationale de la Recherche (ANR) ANR-23-CE11-0029Agence Nationale de la Recherche (ANR) Labex ARCANE ANR-17-EURE-0003EC | European Research Council (ERC) No 772178Fondation pour la Recherche Médicale (FRM) FDT202204014744
6 · The paper itself

Abstract

Bacterial shape and division rely on the dynamics of cell wall assembly, which involves regulated synthesis and cleavage of the peptidoglycan. In ovococci, these processes are coordinated within an annular mid-cell region with nanometric dimensions. More precisely, the cross-wall synthesized by the divisome is split to generate a lateral wall, whose expansion is insured by the insertion of the so-called peripheral peptidoglycan by the elongasome. Septum cleavage and peripheral peptidoglycan synthesis are, thus, crucial remodeling events for ovococcal cell division and elongation. The structural DivIVA protein has long been known as a major regulator of these processes, but its mode of action remains unknown. Here, we integrate click chemistry-based peptidoglycan labeling, direct stochastic optical reconstruction microscopy, and

Indexed as

Bacterial ProteinsStreptococcus pneumoniaeCell CycleCell Cycle ProteinsCell DivisionCell WallPeptidoglycanBacterial ProteinsCell Cycle ProteinsDivIVA protein, bacteriaPeptidoglycancell divisioncell elongationcell morphogenesiscell wallclick chemistryDivIVAdSTORMovococcipeptidoglycanstimulated-emission-depletion microscopyStreptococcus pneumoniaesuper-resolution microscopy

Identifiers

PMID39287436
PMCPMC11481917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.