Evidence map›Paper›PMID 39287422›Full record

ArticleEmerging microbes & infections2024

Genomic characterization of highly pathogenic H5 avian influenza viruses from Alaska during 2022 provides evidence for genotype-specific trends of spatiotemporal and interspecies dissemination.

Christina A Ahlstrom, Mia Kim Torchetti, Julianna Lenoch, Kimberlee Beckmen, Megan Boldenow, Evan J Buck, Bryan Daniels, Krista Dilione, Robert Gerlach, Kristina Lantz and 10 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Christina A AhlstromUS Geological Survey, Alaska Science Center, Anchorage, AK, US.
Mia Kim TorchettiUS Department of Agriculture, National Veterinary Services Laboratories, Ames, IA, US.
Julianna LenochUS Department of Agriculture, APHIS Wildlife Service, National Wildlife Disease Program, Fort Collins, CO, US.
Kimberlee BeckmenAlaska Department of Fish and Game, Fairbanks, AK, US.
Megan BoldenowUS Fish and Wildlife Service, Anchorage, AK, US.
Evan J BuckUS Geological Survey, Alaska Science Center, Anchorage, AK, US.
Bryan DanielsUS Fish and Wildlife Service, Yukon Delta National Wildlife Refuge, Bethel, AK, US.
Krista DilioneUS Department of Agriculture, APHIS Wildlife Service, National Wildlife Disease Program, Fort Collins, CO, US.
Robert GerlachAlaska Department of Environmental Conservation, Anchorage, AK, US.
Kristina LantzUS Department of Agriculture, National Veterinary Services Laboratories, Ames, IA, US.
Angela MatzUS Fish and Wildlife Service, Anchorage, AK, US.
Rebecca L PoulsonUniversity of Georgia, Athens, GA, US.
Laura C ScottUS Geological Survey, Alaska Science Center, Anchorage, AK, US.
Gay SheffieldMarine Advisory Program, Alaska Sea Grant, University of Alaska Fairbanks, Nome, AK, US.
David SinnettUS Department of Agriculture, APHIS Wildlife Service, National Wildlife Disease Program, Palmer, AK, US.
David E StallknechtUniversity of Georgia, Athens, GA, US.
Raphaela StimmelmayrDepartment of Wildlife Management, North Slope Borough, Utqiagvik, AK, US.
Eric TaylorUS Fish and Wildlife Service, Anchorage, AK, US.
Alison R WilliamsUS Fish and Wildlife Service, Izembek National Wildlife Refuge, Cold Bay, AK, US.
Andrew M RameyUS Geological Survey, Alaska Science Center, Anchorage, AK, US.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ongoing panzootic of highly pathogenic H5 clade 2.3.4.4b avian influenza (HPAI) spread to North America in late 2021, with detections of HPAI viruses in Alaska beginning in April 2022. HPAI viruses have since spread across the state, affecting many species of wild birds as well as domestic poultry and wild mammals. To better understand the dissemination of HPAI viruses spatiotemporally and among hosts in Alaska and adjacent regions, we compared the genomes of 177 confirmed HPAI viruses detected in Alaska during April-December 2022. Results suggest multiple viral introductions into Alaska between November 2021 and August or September 2022, as well as dissemination to areas within and outside of the state. Viral genotypes differed in their spatiotemporal spread, likely influenced by timing of introductions relative to population immunity. We found evidence for dissemination of HPAI viruses between wild bird species, wild birds and domestic poultry, as well as wild birds and wild mammals. Continued monitoring for and genomic characterization of HPAI viruses in Alaska can improve our understanding of the evolution and dispersal of these economically costly and ecologically relevant pathogens.

Indexed as

Animals, WildBirdsGenome, ViralGenotypeInfluenza in BirdsPhylogenyAlaskaAnimalsGenomicsInfluenza A virusInfluenza A Virus, H5N1 SubtypeMammalsPoultrySpatio-Temporal Analysisavian influenzabird fluMolecular epidemiologypathogen evolutionpathogen genomics

Identifiers

PMID39287422
PMCPMC11443546

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.