Evidence map›Paper›PMID 39287382›Full record

ArticlemSystems2024

The developing pig respiratory microbiome harbors strains antagonistic to common respiratory pathogens.

Abel A Vlasblom, Birgitta Duim, Shriram Patel, Roosmarijn E C Luiken, Daniel Crespo-Piazuelo, Julia Eckenberger, Chloe E Huseyin, Peadar G Lawlor, Christian Elend, Jaap A Wagenaar and 2 more

Abstract read
In one paragraph

Article in mSystems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abel A VlasblomFaculty of Veterinary Medicine, Division of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-9186-9515
Birgitta DuimFaculty of Veterinary Medicine, Division of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-3568-4978
Shriram PatelSchool of Microbiology and APC Microbiome Ireland, University College Cork, Cork, Ireland.
Roosmarijn E C LuikenFaculty of Veterinary Medicine, Division of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands.
Daniel Crespo-PiazueloPig Development Department,Teagasc Animal & Grassland Research & Innovation Centre, Moorepark, Fermoy, Co. Cork, Ireland.
Julia EckenbergerSchool of Microbiology and APC Microbiome Ireland, University College Cork, Cork, Ireland.
Chloe E HuseyinSchool of Microbiology and APC Microbiome Ireland, University College Cork, Cork, Ireland.
Peadar G LawlorPig Development Department,Teagasc Animal & Grassland Research & Innovation Centre, Moorepark, Fermoy, Co. Cork, Ireland.
Christian ElendEW Nutrition Innovation GmbH & Co.KG, Cologne, Germany.
Jaap A WagenaarFaculty of Veterinary Medicine, Division of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands.
Marcus J ClaessonSchool of Microbiology and APC Microbiome Ireland, University College Cork, Cork, Ireland.
Aldert L ZomerFaculty of Veterinary Medicine, Division of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-0758-5190

Funding

Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) JPI-AMR-2017-1-AJoint Programming Initiative on Antimicrobial Resistance (JPIAMR) JPIAMR-2017-1-BScience Foundation Ireland (SFI) 17/CDA/4765Science Foundation Ireland (SFI) SFI/12/RC/2273_P2ZonMw (Netherlands Organisation for Health Research and Development) 50-52900-98-043ZonMw (Netherlands Organisation for Health Research and Development) 549003004
6 · The paper itself

Abstract

In the global efforts to combat antimicrobial resistance and reduce antimicrobial use in pig production, there is a continuous search for methods to prevent and/or treat infections. Within this scope, we explored the relationship between the developing piglet nasal microbiome and (zoonotic) bacterial pathogens from birth until 10 weeks of life. The nasal microbiome of 54 pigs was longitudinally studied over 16 timepoints on 9 farms in 3 European countries (Germany, Ireland, and the Netherlands) using amplicon sequencing targeting the V3-V4 16S rRNA region as well as the IMPORTANCE: Our study on the nasal microbiota development in piglets across farms in three European countries found that the microbiomes developed similarly in all locations. Additionally, we observed that the colonization of porcine pathogens was either positively or negatively associated with the presence of other bacterial species. These findings enhance our knowledge of co-colonizing species in the nasal cavity and the identified microbial interactions that can be explored for the development of interventions to control pathogens in porcine husbandry.

Indexed as

MicrobiotaRNA, Ribosomal, 16SAnimalsBacteriaFemaleGermanyNasal CavityNoseSwineRNA, Ribosomal, 16Scolonizationmicrobiomemicrobiome developmentnasalporcinerespiratory pathogens

Identifiers

PMID39287382
PMCPMC11494925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.