ArticleLa Tunisie medicale2024
Congenital heart disease: Epidemiological, genetic and evolutive profil.
Article in La Tunisie medicale, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Predictive value of oxygen delivery and regional oxygen saturation during cardiopulmonary bypass for cardiac surgery-associated acute kidney injury in neonates with congenital heart disease.American journal of translational research · 2026Article
- Clinical Value of Serum APOC1, LMNA, and TPM4 in Predicting Fetal Cardiac Abnormalities in Elderly Parturients.International journal of women's health · 2026Article
- Fetal echocardiography combined with serum biomarkers for early diagnosis of congenital heart disease and birth defect risk prediction.American journal of translational research · 2026Article
- Nationwide Survey on Neonatal Critical Congenital Cardiopathies in Mexico: Data from 76 Public Health Service Hospital Units.International journal of neonatal screening · 2025Article
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13 authors.
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Abstract
introductionCongenital heart disease is a heterogeneous group of malformations and one of the most common causes of mortality in children.
aimThe aim of this study was to investigate the clinical, genetic and evolutive characteristics of congenital heart disease.
methodsA retrospective, descriptive study was carried out between 2020 and 2023 at the pediatrics and neonatology department of Mongi Slim university hospital of Tunis. All children with confirmed congenital heart disease were included.
resultsForty-five patients were included, representing 5.7‰ of all admissions. The sex ratio was 1.4. A prenatal diagnosis of congenital heart disease was established in 9% of cases. The median age at the time of discovery was 18 days. The initial symptomatology was respiratory distress in 64% of cases. The main reasons for performing a cardiac ultrasound were heart murmur in 38% followed by polymalformative assessment in 27% of cases. Most of the cardiopathies were atrial septal defects (42%) and ventricular septal defects (40%). Cyanotic heart diseases represented 29% of cases, conotruncal ones 13% and ductodependent ones 16%. Congenital heart disease was associated with a genetic anomaly in 53% of patients, including 15 cases of trisomy 21 and four Di-George syndromes. The treatment was mainly medical (38%), associated with surgery in 5 cases. Death occurred in nine patients, representing a mortality rate of 20%.
conclusionEfforts still need to be made to improve pre- and post-natal diagnosis and ensure rapid treatment in order to reduce morbidity and mortality in our country.
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