Evidence map›Paper›PMID 39287103›Full record

ArticleChemistry & biodiversity2025

Phytochemical Characterization and Assessment of Antioxidant and Anti-Alzheimer Effects of Algerian Seseli Tortuosum.

Abdelkader Slimani, Wail Akkal, Ahmed Acheraf Benmekhbi, Asma Mosbah, Yavuz Selim Cakmak, Mostefa Lefahal, Ahlem Bousetla, El Hassen Mokrani, Chawki Bensouici, Hocine Laouer and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Molecules (Basel, Switzerland) · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abdelkader SlimaniUnit of the Valorization of Natural Resources, BioactiveMolecules and Physicochemical and Biological Analysis, Faculty of Exact Sciences, University Constantine 1, Constantine, 25000, Algeria.
Wail AkkalLaboratory of Applied Biochemistry, Faculty of Natural and Life Sciences, University Constantine 1, Constantine, 25000, Algeria.
Ahmed Acheraf BenmekhbiLaboratory of Applied Biochemistry, Faculty of Natural and Life Sciences, University Constantine 1, Constantine, 25000, Algeria.
Asma MosbahLaboratory of Applied Biochemistry, Faculty of Natural and Life Sciences, University Constantine 1, Constantine, 25000, Algeria.
Yavuz Selim CakmakAksaray University, Faculty of Science and Letters, Department of Biotechnology and Molecular Biology, 68100, Aksaray, Turkey.
Mostefa LefahalUnit of the Valorization of Natural Resources, BioactiveMolecules and Physicochemical and Biological Analysis, Faculty of Exact Sciences, University Constantine 1, Constantine, 25000, Algeria.
Ahlem BousetlaUnit of the Valorization of Natural Resources, BioactiveMolecules and Physicochemical and Biological Analysis, Faculty of Exact Sciences, University Constantine 1, Constantine, 25000, Algeria.
El Hassen MokraniLaboratory of Applied Biochemistry, Faculty of Natural and Life Sciences, University Constantine 1, Constantine, 25000, Algeria.
Chawki BensouiciLaboratoire de Biochimie, Biotechnologie et Division Santé, Centre de Recherche en Biotechnologie, 25000, Constatine, Algeria.
Hocine LaouerLaboratory for the Valorization of Natural Biological Resources, Ferhat Abbas University, Setif, 19000, Algeria.
Salah AkkalUnit of the Valorization of Natural Resources, BioactiveMolecules and Physicochemical and Biological Analysis, Faculty of Exact Sciences, University Constantine 1, Constantine, 25000, Algeria.
Gema NietoDepartment of Food Technology, Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence Campus Mare Nostrum", University of Murcia, Espinardo, 30071, Murcia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HPLC analysis, phytochemical screening, thin layer chromatography, polyphenols and flavonoid contents were conducted to determine the bioactive contents of the Algerian Seseli tortuosum plant. Antioxidant activity was tested using DPPH and ABTS scavenging assays, reducing power, phenanthroline and silver nanoparticle (SNP) assays. The anti-Alzheimer's activity of extracts was also performed in vitro and in silico. Phytochemical analysis highlighted the richness ofthe extracts in terms of coumarins, terpenoids and quercetin. The quantitative determination of total polyphenols and flavonoids showed that the highest amounts occurredinthe dichloromethane (DCME) and methanolic (MeOH) extracts. The antioxidant activities indicated a moderate potential. Compared with galantamine, DCME had a significantly greater anti-Alzheimer effect on BChE(CI

Indexed as

Alzheimer DiseaseAntioxidantsPhytochemicalsAcetylcholinesteraseAlgeriaBenzothiazolesBiphenyl CompoundsFlavonoidsHumansPicratesPlant ExtractsSulfonic Acids1,1-diphenyl-2-picrylhydrazyl2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acidAcetylcholinesteraseAntioxidantsBenzothiazolesBiphenyl CompoundsFlavonoidsPhytochemicalsPicratesPlant ExtractsSulfonic AcidsAnti-Alzheimer activityAntioxidant activityin silico studyPhytochemical analysisSeseli Trotuosum

Identifiers

PMID39287103
PMCPMC11741157

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.