Evidence map›Paper›PMID 39286963›Full record

ArticleAmerican journal of hematology2024

Clearance of pathogenic erythrocytes is maintained despite spleen dysfunction in children with sickle cell disease.

Abdoulaye Sissoko, Astan Cissé, Clémence Duverdier, Mickaël Marin, Lucie Dumas, Sandra Manceau, Blandine Maître, Anita Eckly, Aurélie Fricot-Monsinjon, Camille Roussel and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Abdoulaye SissokoUniversité Paris Cité, Inserm, BIGR, Paris, France.ORCID 0000-0002-9986-0494
Astan CisséUniversité Paris Cité, Inserm, BIGR, Paris, France.
Clémence DuverdierUniversité Paris Cité, Inserm, BIGR, Paris, France.
Mickaël MarinUniversité Paris Cité, Inserm, BIGR, Paris, France.ORCID 0000-0002-4094-022X
Lucie DumasUniversité Paris Cité, Inserm, BIGR, Paris, France.
Sandra ManceauLaboratoire d'Excellence GR-Ex, Paris, France.
Blandine MaîtreUniversité de Strasbourg, UMR_S1255, INSERM, Établissement Français du Sang-Grand Est, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.
Anita EcklyUniversité de Strasbourg, UMR_S1255, INSERM, Établissement Français du Sang-Grand Est, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.
Aurélie Fricot-MonsinjonUniversité Paris Cité, Inserm, BIGR, Paris, France.
Camille RousselUniversité Paris Cité, Inserm, BIGR, Paris, France.
Papa Alioune NdourUniversité Paris Cité, Inserm, BIGR, Paris, France.
Michael DussiotUniversité de Paris, U1163, Mécanismes cellulaires et moléculaires des désordres hématologiques et implications thérapeutiques, INSERM, Paris, France.
Safi DokmakDepartment of HPB surgery and Liver Transplantation, AP-HP, Beaujon Hospital, DMU DIGEST, Clichy, France.
Béatrice AussilhouDepartment of HPB surgery and Liver Transplantation, AP-HP, Beaujon Hospital, DMU DIGEST, Clichy, France.
Jeanne DembinskiDepartment of HPB surgery and Liver Transplantation, AP-HP, Beaujon Hospital, DMU DIGEST, Clichy, France.
Alain SauvanetDepartment of HPB surgery and Liver Transplantation, AP-HP, Beaujon Hospital, DMU DIGEST, Clichy, France.
François PayeAssistance publique des hôpitaux de Paris, Paris, France.
Mickaël LesurtelDepartment of HPB surgery and Liver Transplantation, AP-HP, Beaujon Hospital, DMU DIGEST, Clichy, France.
Jérôme CrosDepartment of Pathology, Université Paris Cité - FHU MOSAIC, Beaujon Hospital, Clichy, France.
Dominique WendumAP-HP. Sorbonne Université, Hôpital St Antoine, Paris, France.
Magali TichitHistopathology Core Facility, Institut Pasteur, Université Paris Cité, Paris, France.
David HardyHistopathology Core Facility, Institut Pasteur, Université Paris Cité, Paris, France.
Carmen CapitoAssistance publique des hôpitaux de Paris, Paris, France.
Slimane AllaliAssistance publique des hôpitaux de Paris, Paris, France.ORCID 0000-0001-7068-4530
Pierre BuffetUniversité Paris Cité, Inserm, BIGR, Paris, France.

Funding

Multifidelity and multiscale modeling of the spleen function in sickle cell disease with in vitro, ex vivo and in vivo validationsR01HL154150 · NHLBI · BROWN UNIVERSITY · PI Pierre BUFFET, Ming Dao · 2020 to 2026
$3.9M
Agence Nationale de la Recherche RS30J20ANR29_SPLEENMARKNHLBI NIH HHS R01 HL154150NIH HHS R21087HH
6 · The paper itself

Abstract

In children with sickle cell disease (SCD), splenectomy is immediately beneficial for acute sequestration crises and hypersplenism (ASSC/HyS) but portends a long-term risk of asplenia-related complications. We retrieved peripheral and splenic red blood cells (RBCs) from 17 SCD children/teenagers undergoing partial splenectomy for ASSC/HyS, 12 adult subjects without RBC-related disease undergoing splenectomy (controls), five human spleens perfused ex vivo with Hb

Indexed as

Anemia, Sickle CellErythrocytes, AbnormalSpleenSplenectomyAdolescentAdultChildChild, PreschoolErythrocytesFemaleHumansHypersplenismMaleYoung Adult

Identifiers

PMID39286963
PMCPMC11560635

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.