Evidence map›Paper›PMID 39286527›Full record

ArticleComputational and structural biotechnology journal2024

Structural insight into the function of human peptidyl arginine deiminase 6.

Jack P C Williams, Stephane Mouilleron, Rolando Hernandez Trapero, M Teresa Bertran, Joseph A Marsh, Louise J Walport

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jack P C WilliamsDepartment of Chemistry, Imperial College London, London, United Kingdom.
Stephane MouilleronStructural Biology Science Technology Platform, The Francis Crick Institute, London, United Kingdom.
Rolando Hernandez TraperoMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
M Teresa BertranProtein-Protein Interaction Laboratory, The Francis Crick Institute, London, United Kingdom.
Joseph A MarshMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Louise J WalportDepartment of Chemistry, Imperial College London, London, United Kingdom.

Funding

Wellcome Trust CC2030
6 · The paper itself

Abstract

Peptidyl arginine deiminase 6 (PADI6 or PAD6) is vital for early embryonic development in mice and humans, yet its function remains elusive. PADI6 is less conserved than other PADIs and it is currently unknown whether it has a catalytic function. Here we show that human PADI6 dimerises like hPADIs 2-4, however, does not bind Ca

Indexed as

CitrullinationInfertilityPeptidyl arginine deiminaseProtein foldingProtein mutation damage predictionX-Ray crystallography

Identifiers

PMID39286527
PMCPMC11402830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.