Evidence map›Paper›PMID 39286353›Full record

ArticleInternational journal of nanomedicine2024

Multiomic Profiling and Neuroprotective Bioactivity of

Vincenzo Vestuto, Marisa Conte, Mariapia Vietri, Francesca Mensitieri, Valentina Santoro, Anna Di Muro, Mariaevelina Alfieri, Maria Moros, Maria Rosaria Miranda, Chiara Amante and 10 more

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Vincenzo Vestuto *Department of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Marisa Conte *Department of Pharmacy, University of Salerno, Fisciano, 84084, Italy.ORCID 0000-0002-7649-2860
Mariapia Vietri *Department of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Francesca MensitieriDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, 84081, Italy.
Valentina SantoroDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Anna Di MuroDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Mariaevelina AlfieriClinical Pathology, Santobono-Pausilipon Children's Hospital, AORN, Naples, 80122, Italy.
Maria MorosInstituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza, Spain.
Maria Rosaria MirandaDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Chiara AmanteDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Matteo Delli CarriDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Pietro CampigliaDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Fabrizio Dal PiazDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, 84081, Italy.
Pasquale Del GaudioDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Nunziatina De TommasiDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Antonietta LeoneDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Ornella MoltedoDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Giacomo PepeDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Elisa CappettaDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.
Alfredo AmbrosoneDepartment of Pharmacy, University of Salerno, Fisciano, 84084, Italy.ORCID 0000-0002-1897-4028

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Extracellular vesicles (EVs) are promising tools for nanomedicine and nanobiotechnology. The purification of mammalian-derived EVs involves intensive processes, and their therapeutic application raises multiple safety and regulatory issues. Plants have the potential to serve as nonconventional sources of therapeutically relevant EVs. In this context, we recently identified hairy roots (HRs) of medicinal plants as a novel biotechnological platform to produce EVs for human health. Methods: Herein, we report the purification, omics profiling, and bioactivity of EVs isolated from HRs of the medicinal plants Results: Conclusion: Collectively, our findings provide compelling evidence that EVs isolated from the hairy roots of

Indexed as

Extracellular VesiclesNeuroprotective AgentsParkinson DiseasePlant RootsSalviaCell Line, TumorHumansMetabolomicsOxidopaminePlant ExtractsProteomicsReactive Oxygen SpeciesNeuroprotective AgentsOxidopaminePlant ExtractsReactive Oxygen Specieshairy rootsnanomedicineneuroprotectionnon-mammalian EV sourceParkinson’s diseaseSalvia extracellular vesicles

Identifiers

PMID39286353
PMCPMC11403015

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.