Evidence map›Paper›PMID 39286333›Full record

ArticleMolecular therapy. Methods & clinical development2024

Predictive power of deleterious single amino acid changes to infer on AAV2 and AAV2-13 capsids fitness.

Tiziana La Bella, Bérangère Bertin, Ante Mihaljevic, Justine Nozi, Patrice Vidal, Sandrine Imbeaud, Jean-Charles Nault, Jessica Zucman-Rossi, Giuseppe Ronzitti

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Advancing AAV technology: From capsid design to scalable manufacturing.Molecular therapy. Methods & clinical development · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tiziana La BellaGenethon, 91000 Evry, France.
Bérangère BertinGenethon, 91000 Evry, France.
Ante MihaljevicGenethon, 91000 Evry, France.
Justine NoziGenethon, 91000 Evry, France.
Patrice VidalGenethon, 91000 Evry, France.
Sandrine ImbeaudCentre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, INSERM, 75000 Paris, France.
Jean-Charles NaultCentre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, INSERM, 75000 Paris, France.
Jessica Zucman-RossiCentre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, INSERM, 75000 Paris, France.
Giuseppe RonzittiGenethon, 91000 Evry, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adeno-associated virus (AAV) is the most widely used vector for

Indexed as

AAV vectorAAV viabilityadeno-associated viruscapsid engineeringdeleterious mutationfitnesshyper variable regionsprediction modelwild-type variant

Identifiers

PMID39286333
PMCPMC11403266

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.