Evidence map›Paper›PMID 39286245›Full record

SynthesisFrontiers in immunology2024

The prognostic utility of

Akram Al-Ibraheem, Ahmed Saad Abdlkadir, Dhuha Ali Al-Adhami, Mike Sathekge, Henry Hee-Seung Bom, Mohammad Ma'koseh, Asem Mansour, Hikmat Abdel-Razeq, Kamal Al-Rabi, Enrique Estrada-Lobato and 4 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Semiquantitative 2-[Frontiers in medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Akram Al-Ibraheem *Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, Jordan.
Ahmed Saad Abdlkadir *Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, Jordan.
Dhuha Ali Al-AdhamiDepartment of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, Jordan.
Mike SathekgeDepartment of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.
Henry Hee-Seung BomDepartment of Nuclear Medicine, Chonnam National University Medical School (CNUMS) and Hospital, Gwangju, Republic of Korea.
Mohammad Ma'kosehDepartment of Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan.
Asem MansourDepartment of Diagnostic Radiology, King Hussein Cancer Center (KHCC), Amman, Jordan.
Hikmat Abdel-RazeqDepartment of Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan.
Kamal Al-RabiDepartment of Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan.
Enrique Estrada-LobatoNuclear Medicine and Diagnostic Section, Division of Human Health, International Atomic Energy Agency (IAEA), Vienna, Austria.
Maysaa Al-HussainiDepartment of Pathology, King Hussein Cancer Center (KHCC), Amman, Jordan.
Ismail MatalkaDepartment of Pathology and Microbiology, King Abdullah University Hospital- Jordan University of Science and Technology, Irbid, Jordan.
Zaid Abdel RahmanDepartment of Nuclear Medicine, Steve Biko Academic Hospital, Pretoria, South Africa.
Stephano FantiNuclear Medicine Department, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chimeric antigen receptor (CAR) T-cell therapy has attracted considerable attention since its recent endorsement by the Food and Drug Administration, as it has emerged as a promising immunotherapeutic modality within the landscape of oncology. This study explores the prognostic utility of [ Methods: PubMed, Scopus, and Ovid databases were explored to search for relevant topics. Dataset retrieval from inception until March 12, 2024, was carried out. The primary endpoints were impact of specific PET metrics on overall survival (OS) and progression-free survival (PFS) before and after treatment. Data from the studies were extracted for a meta-analysis using Stata 17.0. Results: Out of 27 studies identified for systematic review, 15 met the criteria for meta-analysis. Baseline OS analysis showed that total metabolic tumor volume (TMTV) had the highest HR of 2.66 (95% CI: 1.52-4.66), followed by Total-body total lesion glycolysis (TTLG) at 2.45 (95% CI: 0.98-6.08), and maximum standardized uptake values (SUVmax) at 1.30 (95% CI: 0.77-2.19). TMTV and TTLG were statistically significant ( Conclusion: [

Indexed as

Fluorodeoxyglucose F18Immunotherapy, AdoptiveLymphomaPositron-Emission TomographyHumansPrognosisRadiopharmaceuticalsFluorodeoxyglucose F18RadiopharmaceuticalsCAR T-cellCAR T cell therapychimeric antigen receptorFDGimmunotherapymeta-analysismolecular imagingsystematic review

Identifiers

PMID39286245
PMCPMC11402741

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.