Label-free functional imaging of vagus nerve stimulation-evoked potentials at the cortical surface.

Laura RoaFiore, Trevor Meyer, Thaissa Peixoto, Pedro Irazoqui

Abstract read

In one paragraph

Article in Npj biosensing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Update of
Label-Free Functional Imaging of Vagus Nerve Stimulation-Evoked Potentials at the Cortical Surface.2024

5 · Who and what money

Authors and funding

4 authors.

Laura RoaFiore *Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD USA.

Trevor Meyer *Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD USA.

Thaissa PeixotoDepartment of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD USA.

Pedro IrazoquiDepartment of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD USA.

Funding

Sequence of physiological events during oxygen conserving reflex activation leading to sudden death in epilepsyR01NS119390 · NINDS · PURDUE UNIVERSITY · PI KOLIATSOS, VASSILIS E · 2021 to 2025

$2.2M

NINDS NIH HHS R01 NS119390

6 · The paper itself

Abstract

Vagus nerve stimulation (VNS) is an FDA-approved stimulation therapy to treat patients with refractory epilepsy. In this work, we use a coherent holographic imaging system to characterize vagus nerve-evoked potentials (VEPs) in the cortex in response to VNS stimulation paradigms without electrode placement or any genetic, structural, or functional labels. We analyze stimulation amplitude up to saturation, pulse width up to 800 μs, and frequency from 10 Hz to 30 Hz, finding that stimulation amplitude strongly modulates VEPs response magnitude (effect size 0.401), while pulse width has a moderate modulatory effect (effect size 0.127) and frequency has almost no modulatory effect (effect size 0.009) on the evoked potential magnitude. We find mild interactions between pulse width and frequency. This non-contact label-free functional imaging technique may serve as a non-invasive rapid-feedback tool to characterize VEPs and may increase the efficacy of VNS in patients with refractory epilepsy.

Indexed as

Biomedical engineeringImagingMedical imaging

Identifiers

PMID39286049

DOI10.1038/s44328-024-00012-z

PMCPMC11404031

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.