Evidence map›Paper›PMID 39285913›Full record

ArticleBioactive materials2024

3-D bioprinted human-derived skin organoids accelerate full-thickness skin defects repair.

Tao Zhang, Shihao Sheng, Weihuang Cai, Huijian Yang, Jiameng Li, Luyu Niu, Wanzhuo Chen, Xiuyuan Zhang, Qirong Zhou, Chuang Gao and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. [Organoid-based strategies and challenges in tissue regeneration].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tao ZhangDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200433, China.
Shihao ShengDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200433, China.
Weihuang CaiSchool of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200444, China.
Huijian YangDepartment of Laboratory Medicine, Shanghai Zhongye Hospital, Shanghai, 200941, China.
Jiameng LiDepartment of Orthopedics, First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Luyu NiuDepartment of Orthopedics, First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Wanzhuo ChenDepartment of Orthopedics, First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Xiuyuan ZhangDepartment of Orthopedics, First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Qirong ZhouDepartment of Orthopedics, First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Chuang GaoSchool of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200444, China.
Zuhao LiDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200433, China.
Yuanwei ZhangDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200433, China.
Guangchao WangDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200433, China.
Hao ShenDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200433, China.
Hao ZhangDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200433, China.
Yan HuDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200433, China.
Zhifeng YinInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Xiao ChenDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200433, China.
Yuanyuan LiuSchool of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200444, China.
Jin CuiDepartment of Orthopedics, First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Jiacan SuDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200433, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The healing of large skin defects remains a significant challenge in clinical settings. The lack of epidermal sources, such as autologous skin grafting, limits full-thickness skin defect repair and leads to excessive scar formation. Skin organoids have the potential to generate a complete skin layer, supporting in-situ skin regeneration in the defect area. In this study, skin organoid spheres, created with human keratinocytes, fibroblasts, and endothelial cells, showed a specific structure with a stromal core surrounded by surface keratinocytes. We selected an appropriate bioink and innovatively combined an extrusion-based bioprinting technique with dual-photo source cross-linking technology to ensure the overall mechanical properties of the 3D bioprinted skin organoid. Moreover, the 3D bioprinted skin organoid was customized to match the size and shape of the wound site, facilitating convenient implantation. When applied to full-thickness skin defects in immunodeficient mice, the 3D bioprinted human-derived skin organoid significantly accelerated wound healing through in-situ regeneration, epithelialization, vascularization, and inhibition of excessive inflammation. The combination of skin organoid and 3D bioprinting technology can overcome the limitations of current skin substitutes, offering a novel treatment strategy to address large-area skin defects.

Indexed as

3D bioprintingSkin defectSkin organoidWound healing

Identifiers

PMID39285913
PMCPMC11404058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.