ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Integrating amyloid imaging and genetics for early risk stratification of Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Learning a Continuous Progression Trajectory of Amyloid in Alzheimer disease.bioRxiv : the preprint server for biology · 2026Article
- Plasma proteomic Alzheimer's risk score: Biological age clock and pseudotime trajectory.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- An imaging genetics network model for clinical score assessment in Alzheimer's disease.PNAS nexus · 2025Article
- Integrating amyloid imaging and genetics for early risk stratification of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Authors and funding
12 authors.
Funding
Abstract
introductionAlzheimer's disease (AD) initiates years prior to symptoms, underscoring the importance of early detection. While amyloid accumulation starts early, individuals with substantial amyloid burden may remain cognitively normal, implying that amyloid alone is not sufficient for early risk assessment.
methodsGiven the genetic susceptibility of AD, a multi-factorial pseudotime approach was proposed to integrate amyloid imaging and genotype data for estimating a risk score. Validation involved association with cognitive decline and survival analysis across risk-stratified groups, focusing on patients with mild cognitive impairment (MCI).
resultsOur risk score outperformed amyloid composite standardized uptake value ratio in correlation with cognitive scores. MCI subjects with lower pseudotime risk score showed substantial delayed onset of AD and slower cognitive decline. Moreover, pseudotime risk score demonstrated strong capability in risk stratification within traditionally defined subgroups such as early MCI, apolipoprotein E (APOE) ε4+ MCI, APOE ε4- MCI, and amyloid+ MCI. DISCUSSION: Our risk score holds great potential to improve the precision of early risk assessment. HIGHLIGHTS: Accurate early risk assessment is critical for the success of clinical trials. A new risk score was built from integrating amyloid imaging and genetic data. Our risk score demonstrated improved capability in early risk stratification.
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Registered trials
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