Evidence map›Paper›PMID 39285640›Full record

ArticleCell cycle (Georgetown, Tex.)2024

Melatonin protects against defects induced by methoxychlor in porcine oocyte maturation.

Zhaojun Geng, Mingjun Zhang, Shuming Shi, Bing Hu, Liying Liu, Zhichao Chi, Linyi Qu, Yongxun Jin, Xianfeng Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhaojun GengJilin Provincial Key Laboratory of Animal Model, College of Animal Science, Jilin University, Changchun, China.
Mingjun ZhangAnimal Genome Editing Technology Innovation Center, Jilin Province College of Animal Science, Jilin University, Changchun, China.
Shuming ShiJilin Provincial Key Laboratory of Animal Model, College of Animal Science, Jilin University, Changchun, China.
Bing HuAnimal Genome Editing Technology Innovation Center, Jilin Province College of Animal Science, Jilin University, Changchun, China.
Liying LiuJilin Provincial Key Laboratory of Animal Model, College of Animal Science, Jilin University, Changchun, China.
Zhichao ChiJilin Provincial Key Laboratory of Animal Model, College of Animal Science, Jilin University, Changchun, China.
Linyi QuJilin Provincial Key Laboratory of Animal Model, College of Animal Science, Jilin University, Changchun, China.
Yongxun JinJilin Provincial Key Laboratory of Animal Model, College of Animal Science, Jilin University, Changchun, China.
Xianfeng YuJilin Provincial Key Laboratory of Animal Model, College of Animal Science, Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methoxychlor (MXC) is a widely used organochlorine pesticide primarily targeting pests. However, MXC has been found to negatively impact the reproductive system of both humans and animals, triggering oxidative stress and apoptosis. Melatonin (MLT), an endogenous hormone, possesses various benefits, including circadian rhythm regulation and anti-inflammatory and antioxidative stress effects. Moreover, MLT plays a crucial role in the development of animal germ cells and embryos. This study aimed to investigate the impact of MLT on porcine oocytes exposed to MXC. The experimental findings revealed that 200 μM MXC had detrimental effects on the maturation of porcine oocytes. However, the addition of 10

Indexed as

MelatoninMethoxychlorOocytesAnimalsApoptosisDNA DamageEmbryonic DevelopmentFemaleMitochondriaOxidative StressReactive Oxygen SpeciesSwineMelatoninMethoxychlorReactive Oxygen SpeciesDNA damageMelatoninMethoxychlorOocyteOxidative stressPig

Identifiers

PMID39285640
PMCPMC12184135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.