Evidence map›Paper›PMID 39285525›Full record

ReviewImmunological reviews2024

Regulation of immune responses to food by commensal microbes.

Samuel H Light, Cathryn R Nagler

Abstract readReview
In one paragraph

Review in Immunological reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Pathological characteristics of inflammatory bowel diseases.Journal of medical ultrasonics (2001) · 2025
    Review
  7. Beneficial perspective onFrontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Samuel H LightBiological Sciences Division, Department of Microbiology, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-8074-1348
Cathryn R NaglerBiological Sciences Division, Department of Pathology, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-7254-6617

Funding

Mechanisms by which intestinal bacteria contribute to maintenance of tolerance in food allergyR01AI146099 · NIAID · UNIVERSITY OF CHICAGO · PI NAGLER, CATHRYN R · 2020 to 2023
$2.4M
Ecological niche assignment in the gut microbiome on an ecosystem-level scaleR35GM146969 · NIGMS · UNIVERSITY OF CHICAGO · PI Samuel Light · 2022 to 2026
$2.1M
An engineered Clostridial consortia to interrogate immune modulation by secondary bile acidsR21AI186046 · NIAID · UNIVERSITY OF CHICAGO · PI NAGLER, CATHRYN R · 2024 to 2025
$434k
Electrogenic metabolism in host-associated microbial communities andpathogenesisK22AI144031 · NIAID · UNIVERSITY OF CHICAGO · PI LIGHT, SAMUEL · 2020 to 2021
$268k
Food Allergy FundNational Institute of Allergy and Infectious Diseases K22AI144031National Institute of Allergy and Infectious Diseases R21186046National Institute of Allergy and Infectious Diseases RO1AI146099NIAID NIH HHS K22 AI144031NIAID NIH HHS R01 AI146099NIAID NIH HHS R21 AI186046NIGMS NIH HHS R35 GM146969NIGMS NIH HHS R35GM146969
6 · The paper itself

Abstract

The increasing prevalence of immune-mediated non-communicable chronic diseases, such as food allergies, has prompted a deeper investigation into the role of the gut microbiome in modulating immune responses. Here, we explore the complex interactions between commensal microbes and the host immune system, highlighting the critical role of gut bacteria in maintaining immune homeostasis. We examine how modern lifestyle practices and environmental factors have disrupted co-evolved host-microbe interactions and discuss how changes in microbiome composition impact epithelial barrier function, responses to food allergens, and susceptibility to allergic diseases. Finally, we examine the potential of bioengineered microbiome-based therapies, and live biotherapeutic products, for reestablishing immune homeostasis to prevent or treat food allergies.

Indexed as

Food HypersensitivityGastrointestinal MicrobiomeSymbiosisAllergensAnimalsFoodHomeostasisHost Microbial InteractionsHumansImmunomodulationProbioticsAllergensbutyratecommensal bacteriafood allergylive biotherapeutic productsmicrobiome

Identifiers

PMID39285525
PMCPMC11472335

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.