Evidence map›Paper›PMID 39285474›Full record

ArticleGenome biology2024

Atlas of telomeric repeat diversity in Arabidopsis thaliana.

Yueqi Tao, Wenfei Xian, Zhigui Bao, Fernando A Rabanal, Andrea Movilli, Christa Lanz, Gautam Shirsekar, Detlef Weigel

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In one paragraph

Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yueqi TaoDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, 72076, Germany.
Wenfei XianDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, 72076, Germany.
Zhigui BaoDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, 72076, Germany.
Fernando A RabanalDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, 72076, Germany.
Andrea MovilliDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, 72076, Germany.
Christa LanzDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, 72076, Germany.
Gautam ShirsekarDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, 72076, Germany.
Detlef WeigelDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, 72076, Germany. weigel@weigelworld.org.ORCID http://orcid.org/0000-0002-2114-7963

Funding

Novo Nordisk Fonden Novozymes Prize
6 · The paper itself

Abstract

backgroundTelomeric repeat arrays at the ends of chromosomes are highly dynamic in composition, but their repetitive nature and technological limitations have made it difficult to assess their true variation in genome diversity surveys.

resultsWe have comprehensively characterized the sequence variation immediately adjacent to the canonical telomeric repeat arrays at the very ends of chromosomes in 74 genetically diverse Arabidopsis thaliana accessions. We first describe several types of distinct telomeric repeat units and then identify evolutionary processes such as local homogenization and higher-order repeat formation that shape diversity of chromosome ends. By comparing largely isogenic samples, we also determine repeat number variation of the degenerate and variant telomeric repeat array at both the germline and somatic levels. Finally, our analysis of haplotype structure uncovers chromosome end-specific patterns in the distribution of variant telomeric repeats, and their linkage to the more proximal non-coding region.

conclusionsOur findings illustrate the spectrum of telomeric repeat variation at multiple levels in A. thaliana-in germline and soma, across all chromosome ends, and across genetic groups-thereby expanding our knowledge of the evolution of chromosome ends.

Indexed as

ArabidopsisChromosomes, PlantGenetic VariationTelomereEvolution, MolecularGenome, PlantHaplotypesRepetitive Sequences, Nucleic AcidArabidopsisLong readsSatellite repeatsTelomere

Identifiers

PMID39285474
PMCPMC11406999

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.