Evidence map›Paper›PMID 39285382›Full record

ArticleBMC oral health2024

The first description of mucous membrane pemphigoid induced by enalapril maleate: a case report.

Yihang Xie, Qiyue Zhang, Lin Ye, Jiongke Wang, Xin Zeng, Xuefeng Zhang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yihang XieState Key Laboratory of Oral Diseases, National Center of Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Sichuan University, No. 14, Sec. 3 Renminnan Road, Chengdu, Sichuan, 610041, China.
Qiyue ZhangState Key Laboratory of Oral Diseases, National Center of Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Sichuan University, No. 14, Sec. 3 Renminnan Road, Chengdu, Sichuan, 610041, China.
Lin YeState Key Laboratory of Oral Diseases, National Center of Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Sichuan University, No. 14, Sec. 3 Renminnan Road, Chengdu, Sichuan, 610041, China.
Jiongke WangState Key Laboratory of Oral Diseases, National Center of Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Sichuan University, No. 14, Sec. 3 Renminnan Road, Chengdu, Sichuan, 610041, China.
Xin ZengState Key Laboratory of Oral Diseases, National Center of Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Sichuan University, No. 14, Sec. 3 Renminnan Road, Chengdu, Sichuan, 610041, China.
Xuefeng ZhangState Key Laboratory of Oral Diseases, National Center of Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Sichuan University, No. 14, Sec. 3 Renminnan Road, Chengdu, Sichuan, 610041, China. zhangxuefeng1990@scu.edu.cn.

Funding

National Natural Science Foundation of China 82103673 and 82002877
6 · The paper itself

Abstract

backgroundMucous membrane pemphigoid (MMP) is an autoimmune blistering disease (AIBD). Some reports suggest that it has a drug-related pathogenesis especially anti-hypertensive drug. CASE PRESENTATION: A 67-year-old man with a 7-year history of essential hypertension was prescribed enalapril maleate for 5 months. He presented at our department with pain, ulcers, and blisters on the oral mucosa. We performed clinical, histopathology, and direct immunofluorescence examinations, and findings were consistent with the diagnostic criteria for MMP. Consequently, we consulted with the cardiovascular physician and agreed to discontinue the enalapril maleate replacing it with irbesartan/hydrochlorothiazide tablets and topical corticosteroid therapies instead. The lesions healed without recurrence.

conclusionsABID induced by antihypertensive drugs have been reported, and enalapril maleate has been implicated as an antihypertensive agent that may trigger AIBDs, such as MMP. This case highlights the potential relationship between antihypertensive drugs and MMP, of which clinicians should be aware to accurately diagnose and promptly relieve patients' pain.

Indexed as

Antihypertensive AgentsEnalaprilPemphigoid, Benign Mucous MembraneAgedHumansHydrochlorothiazideHypertensionIrbesartanMaleAntihypertensive AgentsEnalaprilHydrochlorothiazideIrbesartanDiagnosisDrug-relatedEnalaprilHypertensionMucous membrane pemphigoid

Identifiers

PMID39285382
PMCPMC11407016

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.