Evidence map›Paper›PMID 39285366›Full record

ArticleBMC infectious diseases2024

Prevalence and macrolide resistance of Mycoplasma genitalium from patients seeking sexual health care in Southern Ghana.

Helena Dela, Eric Behene, Karen Ocansey, Jennifer N Yanney, Kennedy Kwasi Addo, Hugo V Miranda, Andrew G Letizia, Anne T Fox, Terrel Sanders, Naiki Attram

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Helena DelaNaval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana. helena.ogum@gmail.com.
Eric BeheneNaval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana.
Karen OcanseyNaval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana.
Jennifer N YanneyNaval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana.
Kennedy Kwasi AddoNaval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana.
Hugo V MirandaNaval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana.
Andrew G LetiziaNaval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana.
Anne T FoxNaval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana.
Terrel SandersNaval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana.
Naiki AttramNaval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana.

Funding

Global Emerging Infections Surveillance (GEIS) ProMIS ID P115_21_N3
6 · The paper itself

Abstract

backgroundMycoplasma genitalium (MG), a sexually transmitted infection (STI), has emerged as a common cause of non-gonococcal urethritis and cervicitis worldwide, with documented resistance to commonly used antibiotics including doxycycline and azithromycin. Data in Ghana regarding the prevalence of MG is limited.

methodsThis retrospective study investigated MG presence and macrolide resistance among patients who previously reported to selected clinics for STI symptoms between December 2012 and June 2020. Samples were screened for MG and mutations associated with azithromycin resistance were investigated using Nucleic Acid Amplification Testing (NAAT) including the Resistance Plus MG

resultsA total of 1,015 samples were screened, out of which MG infection rate by TIB Molbiol and SpeeDx were 3.1% and 3.4%, respectively. The mutation responsible for macrolide resistance was detected in one MG positive sample by both assays. Both diagnostic tests revealed no significant association between MG infection and socio-demographic characteristics, clinical symptoms, gonorrhea, and chlamydia infection status. There was no significant difference in the mycoplasma percentage positivity rate detected using SpeeDx (3.4%) and TIB Molbiol (3.1%).

conclusionsWhile not commonly tested as a cause of STI symptoms, MG is widespread in Ghana, exhibiting symptoms and prevalence comparable to those in other countries and linked to antimicrobial resistance. Future research using various molecular techniques is essential to monitor resistance trends and guide future antibiotic choices.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialMacrolidesMycoplasma genitaliumMycoplasma InfectionsAdolescentAdultAzithromycinFemaleGhanaHumansMaleMicrobial Sensitivity TestsMiddle AgedMutationPrevalenceAnti-Bacterial AgentsAzithromycinMacrolidesMacrolide resistanceMycoplasma genitaliumNucleic Acid Amplification Test (NAAT)PrevalenceSexually Transmitted Infections (STI)

Identifiers

PMID39285366
PMCPMC11403770

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.