Evidence map›Paper›PMID 39285238›Full record

ArticleScientific reports2024

Profiling of metabolic dysregulation in ovarian cancer tissues and biofluids.

Tsuyoshi Ohta, Masahiro Sugimoto, Yasufumi Ito, Shota Horikawa, Yosuke Okui, Hirotsugu Sakaki, Manabu Seino, Makoto Sunamura, Satoru Nagase

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tsuyoshi OhtaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, Yamagata, 990-9585, Japan. oota-t@med.id.yamagata-u.ac.jp.
Masahiro SugimotoInstitute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, 997-0052, Japan.
Yasufumi ItoDepartment of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, Yamagata, 990-9585, Japan.
Shota HorikawaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, Yamagata, 990-9585, Japan.
Yosuke OkuiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, Yamagata, 990-9585, Japan.
Hirotsugu SakakiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, Yamagata, 990-9585, Japan.
Manabu SeinoDepartment of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, Yamagata, 990-9585, Japan.
Makoto SunamuraDepartment of Intestinal Surgery Medical Center, Tokyo Medical University, Hachioji, Tokyo, 193-0998, Japan.
Satoru NagaseDepartment of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, Yamagata, 990-9585, Japan.

Funding

Japan Society for the Promotion of Science 21K09509Japan Society for the Promotion of Science 21K09532
6 · The paper itself

Abstract

Ovarian cancer (OC) is the most lethal gynecologic cancer, mainly due to late diagnosis with widespread peritoneal spread at first presentation. We performed metabolomic analyses of ovarian and paired control tissues using capillary electrophoresis-mass spectrometry and liquid chromatography-mass spectrometry to understand its metabolomic dysregulation. Of the 130 quantified metabolites, 96 metabolites of glycometabolism, including glycolysis, tricarboxylic acid cycles, urea cycles, and one-carbon metabolites, showed significant differences between the samples. To evaluate the local and systemic metabolomic differences in OC, we also analyzed low or non-invasively available biofluids, including plasma, urine, and saliva collected from patients with OC and benign gynecological diseases. All biofluids and tissue samples showed consistently elevated concentrations of N

Indexed as

MetabolomicsOvarian NeoplasmsAdultAgedBody FluidsChromatography, LiquidElectrophoresis, CapillaryFemaleHumansMass SpectrometryMetabolomeMiddle AgedPolyaminesSalivaSpermineN',N''-diacetylsperminePolyaminesSpermineBiofluidsCancer tissuesMetabolomic dysfunctionNormal tissueOvarian cancer

Identifiers

PMID39285238
PMCPMC11405878

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.