Evidence map›Paper›PMID 39285183›Full record

ArticleScientific reports2024

Identification and biophysical characterization of potential phytochemical inhibitors of carboxyl/choline esterase from Helicoverpa armigera for advancing integrated pest management strategies.

Harry Kaur, Simranjeet Singh, Sandra Kathott Prakash, Surabhi Rode, Sapna Lonare, Rakesh Kumar, Pravindra Kumar, Ashwani Kumar Sharma, Praveen C Ramamurthy, Joginder Singh and 1 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Harry KaurDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Simranjeet SinghInterdisciplinary Centre for Water Research (ICWaR) Indian Institute of Science, Bengaluru, 560012, Karnataka, India.
Sandra Kathott PrakashDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Surabhi RodeDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Sapna LonareDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Rakesh KumarDivision of Crop Improvement, ICAR-Central Institute for Cotton Research (ICAR-CICR), Nagpur, 440010, Maharashtra, India.
Pravindra KumarDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
Ashwani Kumar SharmaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, India. ashwani.sharma@bt.iitr.ac.in.
Praveen C RamamurthyInterdisciplinary Centre for Water Research (ICWaR) Indian Institute of Science, Bengaluru, 560012, Karnataka, India.
Joginder SinghDepartment of Botany, Nagaland University, Lumami, Nagaland, India.
Nadeem A KhanInterdisciplinary Research Center for Membranes and Water Security, King Fahd University of Petroleum and Minerals, 31261, Dhahran, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the realm of disease vectors and agricultural pest management, insecticides play a crucial role in preserving global health and ensuring food security. The pervasive use, particularly of organophosphates (OPs), has given rise to a substantial challenge in the form of insecticide resistance. Carboxylesterases emerge as key contributors to OP resistance, owing to their ability to sequester or hydrolyze these chemicals. Consequently, carboxylesterase enzymes become attractive targets for the development of novel insecticides. Inhibiting these enzymes holds the potential to restore the efficacy of OPs against which resistance has developed. This study aimed to screen the FooDB library to identify potent inhibitory compounds targeting carboxylesterase, Ha006a from the agricultural pest Helicoverpa armigera. The ultimate objective is to develop effective interventions for pest control. The compounds with the highest scores underwent evaluation through docking studies and pharmacophore analysis. Among them, four phytochemicals-donepezil, protopine, 3',4',5,7-tetramethoxyflavone, and piperine-demonstrated favorable binding affinity. The Ha006a-ligand complexes were subsequently validated through molecular dynamics simulations. Biochemical analysis, encompassing determination of IC

Indexed as

CarboxylesteraseInsecticidesMolecular Docking SimulationPhytochemicalsAnimalsCarboxylic Ester HydrolasesCholinesterase InhibitorsHelicoverpa armigeraInsecticide ResistanceMolecular Dynamics SimulationMothsPest ControlCarboxylesteraseCarboxylic Ester HydrolasesCholinesterase InhibitorsInsecticidesPhytochemicalsHydrolaseInsect enzymeInsecticide resistanceInsecticidesOrganophosphatePhytochemicals

Identifiers

PMID39285183
PMCPMC11405510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.