Evidence map›Paper›PMID 39285089›Full record

ArticleMolecular biology reports2024

Innate immunity gene Nod2 protects mice from orthotopic breast cancer.

Serdar Gurses, Nivya Varghese, Dipika Gupta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Serdar GursesIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA.
Nivya VargheseIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA.
Dipika GuptaIndiana University School of Medicine-Northwest, Gary, IN, 46408, USA. dgupta@iu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNod2 is involved in innate immune responses to bacteria, regulation of metabolism, and sensitivity to cancer. A Nod2 polymorphism is associated with breast cancer, but the role of Nod2 in the development and progression of breast cancer is unknown.

methodsHere, we tested the hypothesis that Nod2 protects mice from breast cancer using the 4T1 orthotopic model of mammary tumorigenesis. WT and Nod2

resultsOur data demonstrate that Nod2

conclusionsWe conclude that Nod2 protects mice from the 4T1 orthotopic breast tumor, and that tumors in Nod2

Indexed as

Breast NeoplasmsImmunity, InnateNod2 Signaling Adaptor ProteinAnimalsCell Line, TumorFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticMiceMice, Inbred BALB CMice, KnockoutSignal TransductionSTAT3 Transcription FactorTranscriptomeNod2 protein, mouseNod2 Signaling Adaptor ProteinSTAT3 Transcription FactorBreast cancerInnate immunityNod2Orthotopic tumor modelTranscriptome

Identifiers

PMID39285089
PMCPMC11405536

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.